Alterations in matrix metalloproteinase (MMP) expression and activity are
recognized as key pathogenetic events in several neurological disorders.
This evidence makes MMPs possible therapeutic targets. The search for
substances that can inhibit MMPs is moving progressively toward the
screening of natural products. In particular, marine bioprospecting could
be promising for the discovery of marine natural products with anti-MMP
activities. Despite recent advances in this field, the possibility of using
marine MMP inhibitors (MMPIs) for the treatment of neuroinflammation
is still under-investigated. Here, we review the latest findings in this
promising research field and the potential that marine MMPIs can have in
the management and treatment of various neurological diseases.