The intracellular delivery of nanomaterials and drugs has been attracting
increasing research interest, mainly because of their important effects and
functions in several organelles. Targeting specific organelles can help treat
or decrease the symptoms of diabetes, cancer, infectious, and autoimmune
diseases. Tuning biological and chemical properties enables the creation of
functionalized nanomaterials with enhanced intracellular uptake, ability to escape premature lysosome degradation, and to reach a specific target. Here, we provide an update of recent advances in the intracellular delivery mechanisms that could help drugs reach their target more efficiently.