April 2006 Volume 1, Issue 4 Cancer Therapeutics

The View from Here Robert Strausberg In this Editor's Choice on Cancer Therapeutics we highlight new tools, technologies and clinical approaches that provide an exciting new path for drug development... Read more... Upcoming Issues Issue 5/May '06 Gene Expression Profiling Issue 6/June '06 Imaging Issue 7/July '06 Drug Metabolism Editor's Choice Sign Up for email Update your details Unsubscribe Contact Us xPharm Your first stop for reliable, authoritative information on all aspects of pharmacology. Sign up today for a free, 14-day evaluation.		Drug Discovery Today    Latest issue    home       Top Reviews Chromatin control and cancer-drug discovery: realizing the promise Inche, A. G. and La Thangue, N. B. Drug Discovery Today Recent years have seen major advances in elucidating the complexity of chromatin and its role as an epigenetic regulator of gene expression in eukaryotes. We now have a basic understanding of chromatin control and the enzymatic modifications that impart diverse regulatory cues to the functional activity of the genome... SAGE and related approaches for cancer target identification Porter, D., Yao, J. and Polyak, K. Drug Discovery Today Comprehensive genetic, epigenetic and transcriptional analyses of normal and cancerous tissues and cells have yielded many candidate diagnostic, predictive, and prognostic markers and therapeutic targets in human cancer. This article provides a brief overview of SAGE and SAGE-like techniques, highlighting their utility and advantages relative to other genomic technologies for the discovery of drug targets... Essential properties of drug-targeting delivery systems Petrak, K. Drug Discovery Today How, if at all, can drug delivery help to create ideal drugs? After four decades of trying, an effective site-specific drug-delivery system has not yet been developed. This review draws attention to the pharmacokinetic conditions that must be met to achieve a successful performance by site-selective drug-carrier delivery systems... Click here to subscribe to Drug Discovery Today.   PharmaDiscovery - An Elsevier Event 10-12th May 2006, Bethesda, Maryland Featured session: Innovation in predictive techniques in oncology CHAIR: Peter Lassota, Executive Director, Oncology Disease Area, Novartis Institutes for Biomedical Research Click here to download the conference brochure and/or register.   Abstracts of Key Research Papers A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer Stephens, P. et al. Nat Genet. 2005 Jun;37(6):590-2. Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas Rand, V. et al. Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14344-9. Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants Greulich, H. et al. PLoS Med. 2005 Nov;2(11):e313. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy Paez, J. et al. Science. 2004 Jun 4;304(5676):1497-500. Colorectal cancer: mutations in a signalling pathway Parsons, D.W. et al Nature. 2005 Aug 11;436(7052):792. Mutant PIK3CA promotes cell growth and invasion of human cancer cells Samuels, Y. et al. Cancer Cell. 2005 Jun;7(6):561-73. The colorectal microRNAome Cummins, J.M. et al. Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3687-92. Oncomirs - microRNAs with a role in cancer Esquela-Kerscher, A. and Slack, F.J. Nat Rev Cancer. 2006 Apr;6(4):259-69. Epigenetic transdifferentiation of normal melanocytes by a metastatic melanoma microenvironment Seftor, E.A. et al. Cancer Res. 2005 Nov 15;65(22):10164-9. Oncology exploration: charting cancer medicinal chemistry space Lloyd, D.G. et al. Drug Discov Today. 2006 Feb;11(3-4):149-59. Targeting transcription factors for cancer gene therapy Libermann, T.A. and Zerbini, L.F. Curr Gene Ther. 2006 Feb;6(1):17-33. Oncogenomics and the development of new cancer therapies Strausberg, R.L. et al. Nature. 2004 May 27;429(6990):469-74.	Drug Discovery Today Subscribe Now! Read journal on ScienceDirect RELATED CONFERENCES PharmaDiscovery 2006 SCIpharm 2006 Cardiac Safety Strategies RELATED JOBS Head of Science and Research World Cancer Research Fund International, London, UK [more details] Assistant / Associate Professor, Pharma- cogenomics University of Texas MD Anderson Cancer Center, Houston, Texas [more details] Principal Research Scientist/ Research Advisor Eli Lilly and Company, Indianapolis, Indiana [more details]