April 2007
Volume 2, Issue 4
Drug Delivery
     
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Pharmaceutical Development Scientist
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Sanofi-Aventis
Bridgewater, New Jersey, US

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Lee
The View from Here
Vincent HL Lee

Drug delivery research is undergoing a revolutionary transformation from a passive to an active element in drug product design. At the same time, drug delivery research is becoming increasingly multidisciplinary and computational...
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A review of 2006


  Top Reviews
Designing a molecular delivery system within a preclinical timeframe

Henck JO and Byrn SR
Drug Discovery Today

An understanding of solid-state chemistry, including polymorphism, can reduce the time to filing an investigative new drug (IND) application. Obtaining a stable formulation for IND studies is crucial and must be the focus of much of the early solid-state chemistry research...

The role of nanobiotechnology in drug discovery
blank
Jain, KK

Drug Discovery Today

The application of nanotechnology in life sciences, nanobiotechnology, is already having an impact on diagnostics and drug delivery. Now, researchers are starting to use nanotechnology in the field of drug discovery...

Blood brain barrier genomics and proteomics: elucidating phenotype, identifying disease targets, and enabling brain drug delivery

Calabria AR and Shusta EV
Drug Discovery Today

The blood–brain barrier (BBB) regulates the passage of material between the bloodstream and the brain. Recent genomic and proteomic studies of the BBB have identified some of the unique molecular characteristics of this vascular bed, and have reinforced the concept that the BBB is heavily involved in brain function...


  Abstracts of Key Research Articles

Structure/function relationships of polyamidoamine/DNA dendrimers as gene delivery vehicles
Braun CS, Vetro JA, Tomalia DA, Koe GS, Koe JG, Middaugh CR
J Pharm Sci.
2005;94 (2):423-436.

Structural optimization of a "smart" doxorubicin-polypeptide conjugate for thermally targeted delivery to solid tumors
Furgeson DY, Dreher MR, Chilkoti A
J Control Release. 2006;110 (2):362-369

Novel delivery system based on complexation hydrogels as delivery vehicles for insulin-transferrin conjugates
Kavimandan NJ, Losi E, Peppas NA
Biomaterials. 2006;27(20):3846-3854.

Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models
Kirpotin DB, Drummond DC, Shao Y, Shalaby MR, Hong K, Nielsen UB, Marks JD, Benz CC, Park JW
Cancer Res. 2006;66 (13):6732-6740.

Privileged delivery of polymer nanoparticles to the perinuclear region of live cells via a non-clathrin, non-degradative pathway
Lai SK, Hida K, Man ST, Chen C, Machamer C, Schroer TA, Hanes J
Biomaterials. 2007;28(18):2876-84.

Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus
Lai SK, O'Hanlon DE, Harrold S, Man ST, Wang Y-, Cone R, Hanes J
Proc Natl Acad Sci USA. 2007;104(5):1482-1487.

Sustained vascular endothelial growth factor delivery enhances angiogenesis and perfusion in ischemic hind limb
Sun Q, Chen RR, Shen Y, Mooney DJ, Rajagopalan S, Grossman PM
Pharm Res. 2005;22 (7):1110-1116.

Tat-conjugated PAMAM dendrimers as delivery agents for antisense and siRNA oligonucleotides
Kang H, DeLong R, Fisher MH, Juliano RL
Pharm Res. 2005;22 (12):2099-2106.

Effects of organic anion transporting polypeptide 1B1 haplotype on pharmacokinetics of pravastatin, valsartan, and temocapril
Maeda K, Ieiri I, Yasuda K, Fujino A, Fujiwara H, Otsubo K, Hirano M, Watanabe T, Kitamura Y, Kusuhara H, Sugiyama Y
Clin Pharmacol Ther. 2006;79(5):427-439.

Biomimetic approach to cardiac tissue engineering: Oxygen carriers and channeled scaffolds
Radisic M, Park H, Chen F, Salazar-Lazzaro JE, Wang Y, Dennis R, Langer R, Freed LE, Vunjak-Novakovic G
Tissue Eng. 2006;12(8):2077-2091.


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