Abstracts
of Key Research Articles
Predicting protein interaction sites: binding hot-spots in protein-protein and protein-ligand interfaces
Burgoyne N, Jackson R
Bioinformatics 2006; 22(11): 1335-42
sc-PDB: an annotated database of druggable binding sites from the Protein Data Bank
Kellenberger E, Muller P, Schalon C, Bret G, Foata N, Rognan D
J Chem Inf Model 2006; 46(2): 717-27
Drug-target identification in Drosophila cells: combining high-throughout RNAi and small-molecule screens
Perrimon N, Friedman A, Mathey-Prevot B, Eggert US.
Drug Discov Today. 2007;12(1-2):28-33
From the similarity analysis of protein cavities to the functional classification of protein families using cavbase
Kuhn D, Weskamp N, Schmitt S, Hullermeier E, Klebe G
J Mol Biol. 2006; 359(4): 1023-44
Healthy animals and animal models of human disease(s) in safety assessment of human pharmaceuticals, including therapeutic antibodies
Dixit R and Boelsterli UA
Drug Discov Today. 2007;12(7-8):336-42
Transgenic animals and their impact on the drug discovery industry
Dunn DA, Pinkert CA, Kooyman DL
Drug Discov Today. 2005;10(11):757-67
Structure-based maximal affinity model predicts small-molecule druggability
Cheng AC, Coleman RG Smyth KT, Cao Q, Soulard P, Caffrey DR, Salzberg AC, Huang ES
Nat Biotechnol 2007; 25(1): 71-5
Functional human tissue assays
Hillier C and Bunton D
Drug Discov Today 2007;12(9-10):382-8
Orphan enzymes could be an unexplored reservoir of new drug targets
Lespinet O and Labedan B
Drug Discov Today 2006; 11(7-8):300-5
Pocketome via comprehensive identification and classification of ligand binding envelopes
An J, Totrov M, Abagyan R
Mol Cell Proteomics. 2005;4(6):752-61 |
