December 2007
Volume 2, Issue 12
Best of 2007
     
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International Drug Discovery Specialist
Cell Signaling Technology
Massachusetts, USA

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Pfizer, California, USA

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The University of Dundee
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Pfizer
Kent, UK


Ulrike Knies-Bamforth
The View from Here
Ulrike Knies-Bamforth

At the end of the second year of E-Choice, I would like to thank all the Guest Editors who have contributed to our e-alert for their contributions. In 2007, E-Choice grew in popularity...
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A review of 2006


  Top Reviews
Blood-brain barrier delivery

Pardridge WM
Drug Discovery Today

Neuropharmaceutics is the largest potential growth sector of the pharmaceutical industry. However, this growth is blocked by the problem of the blood–brain barrier (BBB). Essentially 100% of large-molecule drugs and >98% of small-molecule drugs do not cross the BBB...

An anti-aging drug today: from senescence-promoting genes to anti-aging pill

Blagosklonny MV
Drug Discovery Today

Numerous mutations increase lifespan in diverse organisms from worms to mammals. Most genes that affect longevity encode components of the target of rapamycin (TOR) pathway, thus revealing potential targets for pharmacological intervention...

Computationals systems biology in drug discovery and development: methods and applications

Materi W, Wishart DS
Drug Discovery Today

Computational systems biology is an emerging field in biological simulation that attempts to model or simulate intra- and intercellular events using data gathered from genomic, proteomic or metabolomic experiments. The need to model complex temporal and spatiotemporal processes at many different scales...


  Abstracts of Key Research Articles

Nanobiotechnology-based drug delivery to the central nervous system
Jain KK
Neurodegener Dis. 2007; 4(4): 287-91

Active targeting of brain tumours using nanocarriers
Béduneau A, Saulnier P, Benoit JP
Biomaterials 2007; 28(33): 4947-67

On the rate and extent of drug delivery to the brain
Hammarlund-Udenaes M, Fridén M, Syvänen S, Gupta A
Pharm Res. 2007; Dec 5

The highly permeable blood-brain barrier: an evaluation of current opinions about brain uptake capacity
Fagerholm U
Drug Discov Today. 2007; 12:1076-82

Genetics of aging: implications for drug discovery and development
Geesaman BJ
Am J Clin Nutr. 2006; 83(2): 466S-469S

The aging process: where are the drug opportunities?
Smith RG
Curr Opin Chem Biol. 2000; 4(4): 371-6

Growth hormone as an anti-aging therapy – do the benefits outweigh the risks?
Barkan AL
Nat Clin Pract Endocrinol Metab. 2007; 3(7): 508-9

Systems chemical biology
Oprea TI, Tropsha A, Faulon JL, Rintoul MD
Nat Chem Biol. 2007; 3: 447-50

Effective integration of systems biology, biomarkers, biosimulation and modelling in streamlining drug development
Krishna R, Schaefer HG, Bjerrum OJ
Eur J Pharm Sci. 2007; 31: 62-7

Understandiing diseases by a mouse click: the promise and potential of computational approaches in Systems Biology
Klauschen F, Angermann BR, Meier-Schellersheim M
Clin Exp Immunol. 2007; 149: 424-9

 


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