February 2008
Volume 3, Issue 2
Disease Focus: COPD
     
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Cazzola
The View from Here
Mario Cazzola

At present, therapeutic interventions for patients suffering from stable COPD can result in substantial clinical benefit. Although the TORCH study failed in its primary endpoint (statistically significant decrease in mortality), it has been documented...
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March 2008 – The NIH Critical Path

April 2008 – Disease Models

May 2008 – Translational Drug Discovery



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A review of 2006


  Top Reviews
Emerging trends in the therapy of COPD: bronchodilators as mono- and combination therapies

Fitzgerald MF and Fox JC
Drug Discovery Today

Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease that is characterized by progressive airway obstruction that, unlike asthma, is relatively insensitive to bronchodilators and to the classic anti-inflammatory therapy, corticosteroids...

Models for COPD involving cigarette smoke

Martorana PA, Cavarra E, Lucattelli M and Lungarella G
Drug Discovery Today: Disease Models

Chronic obstructive pulmonary disease (COPD) is a major cause of chronic morbidity and mortality throughout the world. Its impact has resulted in dynamic research into the mechanisms involved in the development of this disease and the search for new drugs. In vitro and ex vivo models of COPD involving cigarette smoke...
Interactions between long-acting β2-agonists and glucocorticoids

Caramori G, Ito K, Papi A and Adcock IM
Drug Discovery Today: Therapeutic Strategies

Long acting β2-agonists and glucocorticoids together control asthma in ~95% of affected individuals, although symptoms return after treatment is stopped. Treatment of chronic obstructive pulmonary disease (COPD) scarcely influences the natural course of the disease...


  Abstracts of Key Research Articles

American Thoracic Society; European Respiratory Society Task Force on outcomes of COPD. Outcomes for COPD pharmacological trials: from lung function to biomarkers
Cazzola M, MacNee W, Martinez FJ, Rabe KF, Franciosi LG, Barnes PJ, Brusasco V, Burge PS, Calverley PM, Celli BR, Jones PW, Mahler DA, Make B, Miravitlles M, Page CP, Palange P, Parr D, Pistolesi M, Rennard SI, Rutten-van Mölken MP, Stockley R, Sullivan SD, Wedzicha JA and Wouters EF
Eur Respir J 2008; 31: 416–469

TORCH investigators. Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease
Calverley PM, Anderson JA, Celli B, Ferguson GT, Jenkins C, Jones PW, Yates JC and Vestbo J
N Engl J Med 2007; 356: 775–789

Canadian Thoracic Society/Canadian Respiratory Clinical Research Consortium. Tiotropium in combination with placebo, salmeterol, or fluticasone-salmeterol for treatment of chronic obstructive pulmonary disease: a randomized trial
Aaron SD, Vandemheen KL, Fergusson D, Maltais F, Bourbeau J, Goldstein R, Balter M, O'Donnell D, McIvor A, Sharma S, Bishop G, Anthony J, Cowie R, Field S, Hirsch A, Hernandez P, Rivington R, Road J, Hoffstein V, Hodder R, Marciniuk D, McCormack D, Fox G, Cox G, Prins HB, Ford G, Bleskie D, Doucette S, Mayers I, Chapman K, Zamel N and FitzGerald M
Ann Intern Med 2007; 146: 545–555

Profiling serum biomarkers in patients with COPD: associations with clinical parameters
Pinto-Plata V, Toso J, Lee K, Park D, Bilello J, Mullerova H, De Souza MM, Vessey R and Celli B
Thorax. 2007; 62; 595–601

BOLD Collaborative Research Group. International variation in the prevalence of COPD (the BOLD Study): a population-based prevalence study
Buist AS, McBurnie MA, Vollmer WM, Gillespie S, Burney P, Mannino DM, Menezes AM, Sullivan SD, Lee TA, Weiss KB, Jensen RL, Marks GB, Gulsvik A and Nizankowska-Mogilnicka E
Lancet 2007; 370: 741–750

Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary
Rabe KF, Hurd S, Anzueto A, Barnes PJ, Buist SA, Calverley P, Fukuchi Y, Jenkins C, Rodriguez-Roisin R, van Weel C and Zielinski J
Am J Respir Crit Care Med 2007; 176: 532–555

Mortality in COPD: role of comorbidities
Sin DD, Anthonisen NR, Soriano JB and Agusti AG
Eur Respir J 2006; 28: 1245–1257

From COPD to chronic systemic inflammatory syndrome?
Fabbri LM and Rabe KF
Lancet 2007; 370: 797–799

ATS/ERS Pulmonary Rehabilitation Writing Committee. American Thoracic Society/European Respiratory Society statement on pulmonary rehabilitation
Nici L, Donner C, Wouters E, Zuwallack R, Ambrosino N, Bourbeau J, Carone M, Celli B, Engelen M, Fahy B, Garvey C, Goldstein R, Gosselink R, Lareau S, MacIntyre N, Maltais F, Morgan M, O'Donnell D, Prefault C, Reardon J, Rochester C, Schols A, Singh S and Troosters T
Am J Respir Crit Care Med 2006; 173: 1390–1413

Markers of disease severity in chronic obstructive pulmonary disease
Franciosi LG, Page CP, Celli BR, Cazzola M, Walker MJ, Danhof M, Rabe KF and Della Pasqua OE
Pulm Pharmacol Ther 2006; 19; 189–199

Reduction of morbidity and mortality by statins, angiotensin-converting enzyme inhibitors, and angiotensin receptor blockers in patients with chronic obstructive pulmonary disease
Mancini GB, Etminan M, Zhang B, Levesque LE, FitzGerald JM and Brophy JM
J Am Coll Cardiol 2006; 47: 2554–2560


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