January 2006 Volume 1, Issue 1 cell-based screening

The View from Here Ulrike Knies-Bamforth Welcome. This inaugural issue of eChoice focuses on Cell Based Screening - it's a collection of leading articles, abstracts and editorials we believe are of relevance to you on this topic. . . Upcoming Issues Issue 2/ Feb'06    Biomarkers Issue 3/ March'06 Cancer Therapeutics Issue 4/ April'06    Bioinformatics Editor's Choice Sign Up for email Update your details Unsuscribe Contact Us

Drug Discovery Today    Latest issue    home         Top Reviews High-throughput target discovery using cell-based genetics P. David Jackson and John J. Harrington Drug Discovery Today High-throughput target discovery requires robust disease models and the ability to rapidly survey the genome for function. In the post-genomics era, there has been a strong emphasis placed upon ‘gene-to-function’ approaches that take advantage of the large amount of gene sequence information now available... Cell culture-based models for intestinal permeability: a critique Praveen V. Balimane and Saeho Chong Drug Discovery Today The model systems that are currently used to determine the intestinal permeability characteristics of discovery... Multiplexed high content screening assays create a systems cell biology approach to drug discovery D. Lansing Taylor and Kenneth A. Giuliano Drug Discovery Today: Technologies High content screening (HCS) has emerged as an important platform technology for early drug discovery from target... Click here for great discounts for new subscribers to Drug Discovery Today.   PharmaDiscovery 2006 10-12th May 2006, Bethesda North Hotel and Conference Centre, Maryland Cell-based and whole animal imaging strategies Session Chair: Dr Craig Muir, Vice President, Platform Technology, Millennium Pharmaceuticals Click Here to Download the PharmaDiscovery 2006 Conference Brochure and/or Register.   Abstracts of Key Research Papers Visualization and interpretation of high content screening data J Chem Inf Model. 2006 Jan-Feb;46(1):201-7 High-throughput screening of cell death inducible short peptides from TNF-related apoptosis-inducing ligand sequence FEBS Lett. 2006 Jan 19. doi:10.1016/j.febslet.2006.01.010 Visualization and interpretation of high content screening data J Chem Inf Model. 2006 Jan-Feb;46(1):201-7 Discovery of novel immunostimulants by dendritic cell-based functional screening Blood 2005 Nov 1;106(9):3082-9. Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling Nat Biotechnol. 2005 Oct;23(10):1303-7 Improving high-content-screening assay performance by using division-arrested cells Assay Drug Dev Technol. 2005 Oct;3(5):515-23 Differential responses of PPARalpha, PPARdelta, and PPARgamma reporter cell lines to selective PPAR synthetic ligands Anal Biochem. 2005 Sep 1;344(1):8-15 A combined cell based approach to identify P-glycoprotein substrates and inhibitors in a single assay Int J Pharm. 2005 Sep 14;301(1-2):80-8

Drug Discovery Today Subscribe Now! Read full journal on ScienceDirect RELATED CONFERENCES SCIpharm 2006 Cell Based Assays Event RELATED JOBS Senior Lecturer University of Newcastle [more details] Cell Culture Scientists Development (Cramlington Ref AB5) Angel Biotechnology [more details] Lead Scientist Biocatalysis, Pharm Sci (R4-R7) Pfizer [more details]