May 2006 Volume 1, Issue 5 Gene Expression Profiling

The View from Here Bruce Seligmann Gene expression profiling has revolutionized how drug targets and biomarkers are discovered and validated. Moreover, this approach is currently being exploited to elucidate the mechanism of action and specificity of compounds... Read more... Upcoming Issues Issue 6/June '06 Imaging Issue 7/July '06 Drug Metabolism Issue 8/August '06 RNAi for target discovery and validation Editor's Choice Sign Up for email Update your details Unsubscribe Contact Us xPharm Your first stop for reliable, authoritative information on all aspects of pharmacology. Sign up today for a free, 14-day evaluation.		Drug Discovery Today    Latest issue    home       Top Reviews Small organic molecules that modulate gene transcription Jung, D. et al Drug Discovery Today Regulation of gene expression by transcription factors touches all aspects of human biology and often induces extreme phenotypes. Its external, precise control by small organic molecules represents a challenge in chemistry and biology. Here, we summarize recent progress in the field, together with contributions from our laboratory... Combining genome-wide and targeted gene expression profiling in drug discovery: microarrays and real-time PCR Brazeau, D. Drug Discovery Today Genome-wide examination of transcriptional events involved in drug action can provide new foundations for more mechanistic-based studies of the molecular and physiological basis of the effects and disposition of therapeutic agents. Although microarrays offer the allure of assessing gene expression levels for thousands of genes simultaneously, this technology is inherently exploratory in nature and interpretation of the results can be overwhelming and ambiguous... Target discovery in metabolic disease Dohrmann, C. Drug Discovery Today The prevalence of metabolic diseases is taking on epidemic proportions and poses a serious threat to human health. Current treatment options have proven insufficient to cope with obesity and diabetes because they rarely restore normal metabolism and thus leave patients exposed to lifethreatening complications. Successful management of these diseases depends on novel, improved therapeutic strategies targeting early intervention in disease progression... Click here to subscribe to to Drug Discovery Today.   Abstracts of Key Review Articles Reliability and reproducibility issues in DNA microarray measurements Draghici, S. et al. Trends Genet. 2006 Feb;22(2):101-9. Post-transcriptional control of gene expression: a genome-wide perspective Mata, J. et al. Trends Biochem Sci. 2005 Sep;30(9):506-14. Gene regulation by microRNAs Carthew, R.W. Curr Opin Genet Dev. 2006 Apr;16(2):203-8. Genomics of microRNA Kim, N.V. and Nam, J.W. Trends Genet. 2006 Mar;22(3):165-73. Using genome-wide transcriptional profiling to elucidate small-molecule mechanism Butcher, R.A. and Schreiber, S.L. Curr Opin Chem Biol. 2005 Feb;9(1):25-30. MicroRNAs as oncogenes Hammond, S.M. Curr Opin Genet Dev. 2006 Feb;16(1):4-9. Tumor cells caught in the act of invading: their strategy for enhanced cell motility Wang, W. et al. Trends Cell Biol. 2005 Mar;15(3):138-45. Role reversal: the regulation of neuronal gene expression by microRNAs Klein, M.E. et al. Curr Opin Neurobiol. 2005 Oct;15(5):507-13. Using microarray gene signatures to elucidate mechanisms of antibiotic action and resistance Brazas, M.D. and Hancock, R.E. Drug Discov Today. 2005 Sep 15;10(18):1245-52. Functional genomics in antibacterial drug discovery Freiberg, C. and Brotz-Oesterhelt, H. Drug Discov Today. 2005 Jul 1;10(13):927-35.	Drug Discovery Today Subscribe Now! Read journal on ScienceDirect RELATED CONFERENCES Hit to Lead 2006 42nd Annual DIA Meeting 2nd Annual Obesity Drug Development Summit RELATED JOBS Genomics Technology Leader Wyeth Research, Berkshire, UK [more details] Investigator - Biomarker Research Novartis Institutes for BioMedical Research, Cambridge, US [more details] Senior/Principal Scientists Emergent BioSolutions, Gaithersburg, US [more details]