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The View From Here Bruce Seligmann Gene expression: changing the drug discovery paradigm  Gene
expression profiling has revolutionized how drug targets and biomarkers
are discovered and validated. Moreover, this approach is currently being
exploited to elucidate the mechanism of action and specificity of compounds.
There is promise that gene expression profiling will change the mainstream
drug-discovery process. For this to become reality, it is important to develop
gene expression profiling tools that increase the reliability, sensitivity
and accuracy of multiplexed gene-expression measurement. Moreover, is important
to change the focus from reporter gene and single gene assays to direct,
multiplexed measurement of gene expression levels of native cells and tissues.
This issue of Editor's Choice highlights different aspects of gene expression profiling and the application of this approach to therapeutic fields as far-ranging as cancer, neuroscience, metabolic disorder and infectious diseases.
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