September 2006
Volume 1, Issue 9
R&D Strategy
     
2nd Annual GTI International Conference: Pathway Biology in Medicine

Esther Schmid
The View from Here
Esther Schmid, PhD, MBA

Groundbreaking advances in biomedical sciences from "in silico" to "omics" are influencing today's R&D strategies and could provide solutions to the continuing challenge of reducing cost and failure rates...
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Drug Discovery Today    Latest issue    home      

  Top Reviews
Is pharmaceutical R&D just a game of chance or can strategy make a difference?

Schmid, E.F. and Smith, D.A.
Drug Discovery Today

The pharmaceutical industry is currently experiencing turbulent, yet exciting times. Despite widely expressed negative sentiments regarding productivity there are now signs that innovation could yet win the day and bring a fresh wave of breakthrough drugs...

A new formula for finding drugs

Davies, N., Peakman, T. and Arlington, S.
Drug Discovery Today

The pharmaceutical industry concentrates on making drugs that conform to a particular therapeutic profile, but the model that has served the sector so well for so long is now breaking down...


How many genomics targets can a portfolio afford?

Betz, U.A.K.
Drug Discovery Today

The pharmaceutical industry can look back at a history of successful innovations. Although genomics technologies have provided drug discovery pipelines with a plethora of new potential drug targets, solid target validation is crucial to avoiding high attrition rates...

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Abstracts of Key Research Articles

Data integration: challenges for drug discovery
Searls, D.B.
Nature Reviews Drug Discovery, Volume 4, Number 1, pages 45-58

Virtual ligand screening: strategies, perspectives and limitations
Klebe, G.
Drug Discovery Today, Volume 11, Issues 13-14, pages 580-594

Keynote review: structural biology and drug discovery
Congreve, M., Murray, C.W., and Blundell, T.L.
Drug Discovery Today, Volume 10, Issue 13, pages 895-907

Biology calls the targets: combining RNAi and disease biology
Van Es, H.H.G. and Arts, G.-J.
Drug Discovery Today, Volume 10, Issue 20, pages 1385-1391

Foundation Review: Transgenic animals and their impact on the drug discovery industry
Dunn, D.A., Pinkert, C.A., Kooyman, D.L.
Drug Discovery Today, Volume 10, Issue 11, pages 757-767

Finding new drug targets in the 21st century
Lindsay, M.A.
Drug Discovery Today, Volume 10, Issues 23-24, pages 1683-1687

Finding the target after screening the phenotype
Hart, C.P.
Drug Discovery Today, Volume 10, Issue 7, pages 513-519

Critical Review of the role of HTS in drug discovery
Macarron, R.
Drug Discovery Today, Volume 11, Issues 7-8, pages 277-79

Combinatorial biomarkers: from early toxicology assays to patient population profiling
Koop, R.
Drug Discovery Today, Volume 10, Issue 11, pages 781-788

Less is more: the human microdosing concept
Garner, R.C.
Drug Discovery Today, Volume 10, Issue 7, pages 449-451

Using imaging biomarkers to accelerate drug development and clinical trials
Pien, H.H. et al.
Drug Discovery Today, Volume 10, Issue 4, pages 259-266

Opinion: Impact of genetic diagnostics on drug development
Million, R.P.
Nature Reviews Drug Discovery, Volume 5, pages 459-462

Challenges and Opportunities of pharmacogenetics in drug development
March, R.
Future Medicine – Personalized Medicine, Volume 3, Issue 2, pages 195-206

R&D technology investments: misguided and expensive or a better way to discover medicines?
Schmid, E.F. and Smith, D.A.
Drug Discovery Today, Volume 11, issues 17-18, pages 775-784

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