Medicinal Chemistry News for April 2015

Medicinal Chemistry News Archive

Nature Communications Publications on the First X-ray Crystal Structures of Spiegelmers Bound to Protein Targets Nature Communications Publications on the First X-ray Crystal Structures of Spiegelmers Bound to Protein Targets

Anti-CCL2 and anti-C5a Spiegelmers Revealed in Complex with Their TargetsNOXXON Pharma announced today the publication of two new studies in Nature Communications, entitled:• Crystal structure of a mirror-image L-RNA aptamer (Spiegelmer) in complex with the natural L-protein target CCL2 • Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer