Drug Discovery Today - Downloads http://www.drugdiscoverytoday.com/ Copyright Elsevier Ltd Intuitiv Ltd (www.intuitiv.net) Fri, 10 Sep 2010 14:44:39 GMT Drug Discovery Today - Downloads http://www.drugdiscoverytoday.com/ http://www.drugdiscoverytoday.com/_common/img/template/ddt/site-logo.gif Non-coding RNAs and new opportunities for the private sector http://www.drugdiscoverytoday.com/download/347/ Fabrício F. Costa argues that the private sector should start paying more attention to non-coding RNAs to improve the pipeline for drug discovery and drug development and to facilitate the identification of new diagnostic and prognostic markers. Mon, 23 Aug 2010 00:00:00 GMT http://www.drugdiscoverytoday.com/download/347/ Targeted genetic and viral therapy for advanced head and neck cancers http://www.drugdiscoverytoday.com/download/344/ Head and neck cancers usually present with advanced disease, and novel therapies are urgently needed. Here, Pin-I Huang, Ju-Fang Chang, David H. Kirn and Ta-Chiang Liu summarize the available clinical data and discuss challenges and future directions. Fri, 20 Aug 2010 00:00:00 GMT http://www.drugdiscoverytoday.com/download/344/ siRNAs: their potential as therapeutic agents – Part II. Methods of delivery http://www.drugdiscoverytoday.com/download/346/ Sunit Kumar Singh and Praveensingh B. Hajeri discuss the challenges associated with siRNA and the full potential of RNAi for the development of therapeutic tools and drugs. Thu, 19 Aug 2010 00:00:00 GMT http://www.drugdiscoverytoday.com/download/346/ siRNAs: their potential as therapeutic agents – Part I. Designing of siRNAs http://www.drugdiscoverytoday.com/download/345/ Developing precise tools for designing siRNAs can achieve the most efficient knockdown of target genes and reduce off-target effects. Here, Praveensingh B. Hajeri and Sunit Kumar Singh discuss the strategies and parameters required for effective siRNA designing and synthesis. Wed, 18 Aug 2010 00:00:00 GMT http://www.drugdiscoverytoday.com/download/345/ Aptocine-Mediated Systemic Immune Tumor Destruction: An Emerging Intratumoral Whole Cell Autologous Vaccine http://www.drugdiscoverytoday.com/download/250/ This is a white paper addressing the immunotherapeutic potential of the development product Aptocine and puts it in the context of current treatments and other 'cancer vaccines' in development. Mon, 08 Mar 2010 00:00:00 GMT http://www.drugdiscoverytoday.com/download/250/ http://www.drugdiscoverytoday.com/download/170/ Tue, 02 Feb 2010 13:58:12 GMT http://www.drugdiscoverytoday.com/download/170/ The shrinking of the knowledge base – what is the impact of this on the speed and security of drug development? http://www.drugdiscoverytoday.com/download/171/ Paul Branthwaite discusses the implication of reducing the Pharmaceutical industry knowledge base as a result of mergers, acquisitions and a drive to reduce cost base. He specificaly deals with the impact of these changes on the ability to produce innovative pharmaceuticals and the time required so to do. Tue, 02 Feb 2010 00:00:00 GMT http://www.drugdiscoverytoday.com/download/171/