http://www.drugdiscoverytoday.com/ Copyright Elsevier Ltd Intuitiv Ltd (www.intuitiv.net) Wed, 19 Jun 2013 13:12:33 GMT http://www.drugdiscoverytoday.com/ http://www.drugdiscoverytoday.com/_common/img/template/ddt/site-logo.gif http://www.drugdiscoverytoday.com/view/24065/what-makes-a-good-drug-target/ In this article, Isabella Gashaw , Peter Ellinghaus, Anette Sommer and Khusru Asadullah discuss those factors that differentiate good drug targets from poor or the unusable. Wed, 22 Feb 2012 11:44:00 GMT http://www.drugdiscoverytoday.com/view/24065/what-makes-a-good-drug-target/ http://www.drugdiscoverytoday.com/view/22986/drug-discovery-in-the-next-decade-innovation-needed-asap/ The pharmaceutical sector, a cornerstone of the healthcare industry, is undergoing dramaticchange, primarily caused by reduced output of new medicines from research and development(R&D) laboratories, drug pricing pressures, stricter regulatory environments and the overallcurrent economic downturn. This makes demands of all pharmaceutical companies to find better ways to increase their output of new drugs, through innovation, to both treat patients and meet their shareholders’ expectations. Thu, 05 Jan 2012 11:19:00 GMT http://www.drugdiscoverytoday.com/view/22986/drug-discovery-in-the-next-decade-innovation-needed-asap/ http://www.drugdiscoverytoday.com/view/22982/learning-lessons-from-drugs-that-haverecently-entered-the-market/ In this article, the most downloaded of Q2 2011, Simon Teague outlines that the key determinants for success in drug discovery can be defined by studying recently launched drugs. Thu, 05 Jan 2012 10:57:00 GMT http://www.drugdiscoverytoday.com/view/22982/learning-lessons-from-drugs-that-haverecently-entered-the-market/ http://www.drugdiscoverytoday.com/view/22981/the-graphical-representation-of-adme-related-molecule-properties-for-medicinal-chemists/ In this article, the most downloaded of Q1 2011, Timothy J. Ritchie, Peter Ertl and Richard Lewis review various approaches that have been used to represent molecule properties graphically in the context of oral ‘drug likeness’, with the goal of improving the decision making of medicinal chemists during the drug discovery process. Thu, 05 Jan 2012 10:25:00 GMT http://www.drugdiscoverytoday.com/view/22981/the-graphical-representation-of-adme-related-molecule-properties-for-medicinal-chemists/ http://www.drugdiscoverytoday.com/view/15998/cancer-nanotechnology-application-of-nanotechnology-in-cancer-therapy/ In this article, the most downloaded article of Q4 2010, Ranjita Misra, Sarbari Acharya and Sanjeeb K. Sahoo discuss the applications of nanotechnology to the treatment of cancer Wed, 16 Feb 2011 14:00:00 GMT http://www.drugdiscoverytoday.com/view/15998/cancer-nanotechnology-application-of-nanotechnology-in-cancer-therapy/ http://www.drugdiscoverytoday.com/view/15586/getting-physical-in-drug-discovery-a-contemporary-perspective-on-solubility-and-hydrophobicity/ The physical properties of drug molecules are frequently identified as a shortcoming of drugs in development. This article, the most highly-downloaded of Q3 2010, proposes a novel approach to the prediction of water solubility Tue, 01 Feb 2011 14:55:00 GMT http://www.drugdiscoverytoday.com/view/15586/getting-physical-in-drug-discovery-a-contemporary-perspective-on-solubility-and-hydrophobicity/ http://www.drugdiscoverytoday.com/view/15584/pharmacophore-modeling-and-applications-in-drug-discovery-challenges-and-recent-advances/ The most downloaded article from Drug Discovery Today in Q2 2010 was by Sheng-Yong Yang and deals with the application of pharmacophore modeling to drug discovery. Tue, 01 Feb 2011 14:44:00 GMT http://www.drugdiscoverytoday.com/view/15584/pharmacophore-modeling-and-applications-in-drug-discovery-challenges-and-recent-advances/ http://www.drugdiscoverytoday.com/view/15582/visualizing-the-drug-target-landscape/ This article, by Stephen J. Campbell, Anna Gaulton, Jason Marshall, Dmitri Bichko, Sid Martin, Cory Brouwer1 and Lee Harland was the most downloaded article of Q1 2010. It deals with tools to integrate biological, chemical and clinical resources. Tue, 01 Feb 2011 14:32:00 GMT http://www.drugdiscoverytoday.com/view/15582/visualizing-the-drug-target-landscape/ http://www.drugdiscoverytoday.com/view/15573/the-impact-of-aromatic-ring-count-on-compound-developability-are-too-many-aromatic-rings-a-liability-in-drug-design/ The content of the most downloaded article in Q4 2009 deals with the impact of the number of aromatic rings on the ability to deliver quality compounds for drug development. This information and analysis is clearly highly important and directly relevant to the day-to-day work of the medicinal chemist. Tue, 01 Feb 2011 11:00:00 GMT http://www.drugdiscoverytoday.com/view/15573/the-impact-of-aromatic-ring-count-on-compound-developability-are-too-many-aromatic-rings-a-liability-in-drug-design/ http://www.drugdiscoverytoday.com/view/15571/transforming-fragments-into-candidates-small-becomes-big-in-medicinal-chemistry/ Again, medicinal chemistry features highly in our "Most downloaded" spot. This time we feature the extremely hot topic of fragment-based drug discovery, from some of the most influential experts, based in the Netherlands and the UK Tue, 01 Feb 2011 10:15:00 GMT http://www.drugdiscoverytoday.com/view/15571/transforming-fragments-into-candidates-small-becomes-big-in-medicinal-chemistry/ http://www.drugdiscoverytoday.com/view/15569/medicinal-chemistry-strategies-in-follow-on-drug-discovery/ This article was the most downloaded article in the period Q2 2009. A common theme appears with many of our most popular articles in that they frequently relate to medicinal chemistry strategy or practice. I hope that you enjoy this article. Tue, 01 Feb 2011 09:59:00 GMT http://www.drugdiscoverytoday.com/view/15569/medicinal-chemistry-strategies-in-follow-on-drug-discovery/ http://www.drugdiscoverytoday.com/view/6464/drug-discovery-in-the-era-of-facebook-new-tools-for-scientific-networking/ This article is involved with the impact that social networking is beginning to make on drug discovery process. While bioinformaticsand chemoinformatics underpin research at a scientific level, rapid communication between individual researchers across continents now allows the global exchange of ideas, tools and technologies.Networking at this level of speed and reach is quite a recent phenomenon. It facilitates the developmentof common interests, accelerates technology transfer and increases cooperative and competitive behaviour. The article critically evaluates different web-based networking approaches as effectivere sources for the drug discovery scientist. Thu, 14 Jan 2010 13:40:00 GMT http://www.drugdiscoverytoday.com/view/6464/drug-discovery-in-the-era-of-facebook-new-tools-for-scientific-networking/ http://www.drugdiscoverytoday.com/view/3154/drug-discovery-today-highlighted-review-metabolite-likeness-as-a-criterion-in-the-design-and-selection-of-pharmaceutical-drug-libraries/ This highlighted review from Drug Discovery Today by Dobson, Patel and Kell outlines how "metabolite-likeness" in an analogous manner to "drug-likeness" and "lead-likeness" can be used to improve the value of compound libraries design by incorporating features of endogenous metabolites ("endogenites") Tue, 11 Aug 2009 00:00:00 GMT http://www.drugdiscoverytoday.com/view/3154/drug-discovery-today-highlighted-review-metabolite-likeness-as-a-criterion-in-the-design-and-selection-of-pharmaceutical-drug-libraries/ http://www.drugdiscoverytoday.com/view/3132/drug-discovery-today-citation-classic-the-growing-impact-of-click-chemistry-on-drug-discovery/ Welcome to the first article in Drug Discovery Today Citation Classics. I would say that it is very hard to predict what articles will make citation classic articles, but I suppose that having a Nobel Prize-winning author and a topic of great significance to the field of synthetic medicinal chemistry is a pretty good start. Mon, 10 Aug 2009 00:00:00 GMT http://www.drugdiscoverytoday.com/view/3132/drug-discovery-today-citation-classic-the-growing-impact-of-click-chemistry-on-drug-discovery/ http://www.drugdiscoverytoday.com/view/3138/most-downloaded-review-q1-2009-target-discovery-from-data-mining-approaches/ The most downloaded review article from Drug Discovery Today from the first quarter of 2009 deals with the topic of target discovery from the informatics perspective. It would be difficult to overstate the value to Pharma of identifying and validating the most relevant therapeutic targets. In this article, Yang, Adelstein and Kassis outline text mining, its value and limitations and application to target discovery. In addition, they cover the field of emerging and integrated data mining approaches. Mon, 10 Aug 2009 00:00:00 GMT http://www.drugdiscoverytoday.com/view/3138/most-downloaded-review-q1-2009-target-discovery-from-data-mining-approaches/