Free content to accompany the Society for Medicines Research meeting “Medicines Research: Current Trends and Case Histories”

9th December 2008, Queen Elizabeth II Conference Centre, London 

Editorial The innovative medicines initiative: a pre-competitive initiative to enhance the biomedical science base of Europe to expedite the development of new medicines for patients By Jackie Hunter Feature Where is the hope for drug discovery? Let history tell the future By De-Xin Kong, Xue-Juan Li and Hong-Yu Zhang Reviews Fragment-based lead discovery: leads by design By Robin A.E. Carr, Miles Congreve, Christopher W. Murray and David C. Rees Integration of fragment screening and library design By Gregg Siegal, Eiso AB and Jan Schultz Fragments, network biology and designing multiple ligands By Richard Morphy and Zoran Rankovic Progress in targeting HIV-1 entry By Hugues J.-P.Ryser and Rudolf Flückiger Natural products in drug discovery By Alan L. Harvey Is declining innovation in the pharmaceutical industry a myth? By Esther F.Schmid and Dennis A.Smith Monitor Fragment-based drug discovery of carbonic anhydrase II inhibitors by dynamic combinatorial chemistry By Paul Edwards An antitumor dual inhibitor of cyclindependent kinases and Aurora kinases By Andrew Westwell