25 Hottest Articles on Science Direct

The impact of aromatic ring count on compound developability - are too many aromatic rings a liability in drug design? • Review article

Drug Discovery Today, Volume 14, Issue 21-22, November 2009, Pages 1011-1020 | Ritchie, T.J.; Macdonald, S.J.F.
26/02/2010

The road ahead for large pharma: long-term science and innovation • Editorial

Drug Discovery Today, Volume 14, Issue 9-10, May 2009, Pages 439-441 | Lundberg, J.M.; Reilly, C.
20/10/2009

The growing impact of click chemistry on drug discovery • Review article

Drug Discovery Today, Volume 8, Issue 24, December 2003, Pages 1128-1137 | Kolb, H.C.; Sharpless, K.B.
20/10/2009

Homology modeling in drug discovery: current trends and applications • Review article

Drug Discovery Today, Volume 14, Issue 13-14, July 2009, Pages 676-683 | Cavasotto, C.N.; Phatak, S.S.
20/10/2009

Text-based knowledge discovery: search and mining of life-sciences documents • Review article

Drug Discovery Today, Volume 7, Issue 11, May 2002, Pages S89-S98 | Mack, R.; Hehenberger, M.
20/10/2009

Understanding autoimmune disease: new targets for drug discovery • Review article

Drug Discovery Today, Volume 14, Issue 19-20, October 2009, Pages 926-934 | Balague, C.; Kunkel, S.L.; Godessart, N.
26/02/2010

Natural products in drug discovery • Review article

Drug Discovery Today, Volume 13, Issue 19-20, October 2008, Pages 894-901 | Harvey, A.L.
20/10/2009

Brain drug targeting: a computational approach for overcoming blood-brain barrier • Review article

Drug Discovery Today, Volume 14, Issue 21-22, November 2009, Pages 1030-1036 | Mehdipour, A.R.; Hamidi, M.
26/02/2010

The changing landscape of cancer drug discovery: a challenge to the medicinal chemist of tomorrow • Review article

Drug Discovery Today, Volume 14, Issue 21-22, November 2009, Pages 1045-1050 | Pors, K.; Goldberg, F.W.; Leamon, C.P.; Rigby, A.C.; Snyder, S.A.; Falconer, R.A.
26/02/2010

Navigating structure-activity landscapes • Review article

Drug Discovery Today, Volume 14, Issue 13-14, Pages 698-705 | Bajorath, J.; Peltason, L.; Wawer, M.; Guha, R.; Lajiness, M.S.; Van Drie, J.H.
01/12/2009

The impact of synthetic biology on drug discovery • Review article

Drug Discovery Today, Volume 14, Issue 19-20, October 2009, Pages 956-963 | Weber, W.; Fussenegger, M.
26/02/2010

Medicinal chemistry strategies in follow-on drug discovery • Review article

Drug Discovery Today, Volume 14, Issue 9-10, May 2009, Pages 516-522 | Zhao, H.; Guo, Z.
20/10/2009

Proton pump inhibitors: actions and reactions • Review article

Drug Discovery Today, Volume 14, Issue 13-14, Pages 647-660 | Mullin, J.M.; Gabello, M.; Murray, L.J.; Farrell, C.P.; Bellows, J.; Wolov, K.R.; Kearney, K.R.; Rudolph, D.; Thornton, J.J.
01/12/2009

Histone acetyl transferases as emerging drug targets • Review article

Drug Discovery Today, Volume 14, Issue 19-20, October 2009, Pages 942-948 | Dekker, F.J.; Haisma, H.J.
26/02/2010

Developments in fluorescent probes for receptor research • Review article

Drug Discovery Today, Volume 14, Issue 13-14, Pages 706-712 | Leopoldo, M.; Lacivita, E.; Berardi, F.; Perrone, R.
01/12/2009

New tools for functional genomic analysis • Review article

Drug Discovery Today, Volume 14, Issue 15-16, August 2009, Pages 754-760 | Chen, X.; Jorgenson, E.; Cheung, S.T.
26/02/2010

Assessing the bioequivalence of biosimilars • Review article

Drug Discovery Today, Volume 14, Issue 9-10, May 2009, Pages 495-499 | Schellekens, H.
20/10/2009

Drug discovery: new models for industry-academic partnerships • Review article

Drug Discovery Today, Volume 14, Issue 1-2, Pages 95-101 | Tralau-Stewart, C.J.; Wyatt, C.A.; Kleyn, D.E.; Ayad, A.
01/12/2009

NMR methods in fragment screening: theory and a comparison with other biophysical techniques • Review article

Drug Discovery Today, Volume 14, Issue 21-22, November 2009, Pages 1051-1057 | Dalvit, C.
26/02/2010

Making medicinal chemistry more effective-application of Lean Sigma to improve processes, speed and quality • Review article

Drug Discovery Today, Volume 14, Issue 11-12, June 2009, Pages 598-604 | Andersson, S.; Armstrong, A.; Bjore, A.; Bowker, S.; Chapman, S.; Davies, R.; Donald, C.; Egner, B.; Elebring, T.; Holmqvist, S.; Inghardt, T.; Johannesson, P.; Johansson, M.; Johnstone, C.; Kemmitt, P.; Kihlberg, J.; Korsgren, P.; Lemurell, M.; Moore, J.
20/10/2009

Transforming fragments into candidates: small becomes big in medicinal chemistry • Review article

Drug Discovery Today, Volume 14, Issue 13-14, July 2009, Pages 630-646 | de Kloe, G.E.; Bailey, D.; Leurs, R.; de Esch, I.J.P.
20/10/2009

G-protein-coupled receptor-focused drug discovery using a target class platform approach • Review article

Drug Discovery Today, Volume 14, Issue 5-6, March 2009, Pages 231-240 | Heilker, R.; Wolff, M.; Tautermann, C.S.; Bieler, M.
20/10/2009

siRNAs: their potential as therapeutic agents - Part II. Methods of delivery • Review article

Drug Discovery Today, Volume 14, Issue 17-18, September 2009, Pages 859-865 | Singh, S.K.; Hajeri, P.B.
26/02/2010

Target discovery from data mining approaches • Review article

Drug Discovery Today, Volume 14, Issue 3-4, Pages 147-154 | Yang, Y.; Adelstein, S.J.; Kassis, A.I.
01/12/2009

Revealing promiscuous drug-target interactions by chemical proteomics • Review article

Drug Discovery Today, Volume 14, Issue 21-22, November 2009, Pages 1021-1029 | Bantscheff, M.; Scholten, A.; Heck, A.J.R.
26/02/2010