25 Hottest Articles on Science Direct

Natural products in drug discovery • Review article

Drug Discovery Today, Volume 13, Issue 19-20, October 2008, Pages 894-901 | Harvey, A.L.
20/10/2009

The road ahead for large pharma: long-term science and innovation • Editorial

Drug Discovery Today, Volume 14, Issue 9-10, May 2009, Pages 439-441 | Lundberg, J.M.; Reilly, C.
20/10/2009

The growing impact of click chemistry on drug discovery • Review article

Drug Discovery Today, Volume 8, Issue 24, December 2003, Pages 1128-1137 | Kolb, H.C.; Sharpless, K.B.
20/10/2009

The impact of aromatic ring count on compound developability - are too many aromatic rings a liability in drug design? • Review article

Drug Discovery Today, Volume 14, Issue 21-22, November 2009, Pages 1011-1020 | Ritchie, T.J.; Macdonald, S.J.F.
26/02/2010

Follow-on drugs: How far should chemists look? • Review article

Drug Discovery Today, Volume 16, Issue 15-16, August 2011, Pages 722-732 | Giordanetto, F.; Bostrom, J.; Tyrchan, C.
22/12/2011

Text-based knowledge discovery: search and mining of life-sciences documents • Review article

Drug Discovery Today, Volume 7, Issue 11, May 2002, Pages S89-S98 | Mack, R.; Hehenberger, M.
20/10/2009

New promising drug targets in cancer- and metastasis-initiating cells • Review article

Drug Discovery Today, Volume 15, Issue 9-10, May 2010, Pages 354-364 | Mimeault, M.; Batra, S.K.
26/08/2010

Drug discovery in pharmaceutical industry: productivity challenges and trends • Review article

Drug Discovery Today, Volume 17, Issue 19-20, October 2012, Pages 1088-1102 | Khanna, I.
20/11/2012

Essential considerations for using protein-ligand structures in drug discovery • Review article

Drug Discovery Today, Volume 17, Issue 23-24, December 2012, Pages 1270-1281 | Warren, G.L.; Do, T.D.; Kelley, B.P.; Nicholls, A.; Warren, S.D.
02/02/2013

Hydrogels: from controlled release to pH-responsive drug delivery • Review article

Drug Discovery Today, Volume 7, Issue 10, Pages 569-579 | Gupta, P.; Vermani, K.; Garg, S.
01/12/2009

Evolving molecules using multi-objective optimization: applying to ADME/Tox • Review article

Drug Discovery Today, Volume 15, Issue 11-12, June 2010, Pages 451-460 | Ekins, S.; Honeycutt, J.D.; Metz, J.T.
26/08/2010

The Drug Discovery Portal: a resource to enhance drug discovery from academia • Review article

Drug Discovery Today, Volume 15, Issue 15-16, August 2010, Pages 679-683 | Clark, R.L.; Johnston, B.F.; Mackay, S.P.; Breslin, C.J.; Robertson, M.N.; Harvey, A.L.
28/10/2010

PubChem as a public resource for drug discovery • Review article

Drug Discovery Today, Volume 15, Issue 23-24, December 2010, Pages 1052-1057 | Li, Q.; Cheng, T.; Wang, Y.; Bryant, S.H.
11/02/2011

Mobile apps for chemistry in the world of drug discovery • Review article

Drug Discovery Today, Volume 16, Issue 21-22, January 2011, Pages 928-939 | Williams, A.J.; Ekins, S.; Clark, A.M.; Jack, J.J.; Apodaca, R.L.
09/02/2012

Target-drug interactions: first principles and their application to drug discovery • Review article

Drug Discovery Today, Volume 17, Issue 1-2, January 2012, Pages 10-22 | Nunez, S.; Venhorst, J.; Kruse, C.G.
02/06/2012

Brain drug targeting: a computational approach for overcoming blood-brain barrier • Review article

Drug Discovery Today, Volume 14, Issue 21-22, November 2009, Pages 1030-1036 | Mehdipour, A.R.; Hamidi, M.
26/02/2010

Spleen tyrosine kinases: biology, therapeutic targets and drugs • Review article

Drug Discovery Today, Volume 15, Issue 13-14, July 2010, Pages 517-530 | Riccaboni, M.; Bianchi, I.; Petrillo, P.
28/10/2010

Lead optimization in the nondrug-like space • Review article

Drug Discovery Today, Volume 16, Issue 3-4, February 2011, Pages 158-163 | Zhao, H.
28/05/2011

Utility of protein structures in overcoming ADMET-related issues of drug-like compounds • Review article

Drug Discovery Today, Volume 16, Issue 11-12, June 2011, Pages 530-538 | Stoll, F.; Goller, A.H.; Hillisch, A.
03/08/2011

Can we discover pharmacological promiscuity early in the drug discovery process? • Review article

Drug Discovery Today, Volume 17, Issue 7-8, April 2012, Pages 325-335 | Peters, J.U.; Hert, J.; Bissantz, C.; Hillebrecht, A.; Gerebtzoff, G.; Bendels, S.; Tillier, F.; Migeon, J.; Fischer, H.; Guba, W.; Kansy, M.
24/08/2012

Oral delivery of anticancer drugs I: general considerations • Review article

Drug Discovery Today, Volume 18, Issue 41306, January 2013, Pages 25-34 | Mazzaferro, S.; Bouchemal, K.; Ponchel, G.
08/06/2013

The changing landscape of cancer drug discovery: a challenge to the medicinal chemist of tomorrow • Review article

Drug Discovery Today, Volume 14, Issue 21-22, November 2009, Pages 1045-1050 | Pors, K.; Goldberg, F.W.; Leamon, C.P.; Rigby, A.C.; Snyder, S.A.; Falconer, R.A.
26/02/2010

Drug discovery chemistry: a primer for the non-specialist • Review article

Drug Discovery Today, Volume 14, Issue 15-16, August 2009, Pages 731-744 | Jordan, A.M.; Roughley, S.D.
26/02/2010

The nasty surprise of a complex drugdrug interaction • Review article

Drug Discovery Today, Volume 15, Issue 9-10, May 2010, Pages 391-395 | Bode, C.
26/08/2010

Outsourcing lead optimization: the eye of the storm • Review article

Drug Discovery Today, Volume 16, Issue 3-4, February 2011, Pages 147-157 | Clark, D.E.
28/05/2011