25 Hottest Articles on Science Direct

Pharmacophore modeling and applications in drug discovery: challenges and recent advances • Review article

Drug Discovery Today, Volume 15, Issue 11-12, June 2010, Pages 444-450 | Yang, S.Y.
26/08/2010

The road ahead for large pharma: long-term science and innovation • Editorial

Drug Discovery Today, Volume 14, Issue 9-10, May 2009, Pages 439-441 | Lundberg, J.M.; Reilly, C.
20/10/2009

The growing impact of click chemistry on drug discovery • Review article

Drug Discovery Today, Volume 8, Issue 24, December 2003, Pages 1128-1137 | Kolb, H.C.; Sharpless, K.B.
20/10/2009

Drug discovery chemistry: a primer for the non-specialist • Review article

Drug Discovery Today, Volume 14, Issue 15-16, August 2009, Pages 731-744 | Jordan, A.M.; Roughley, S.D.
26/02/2010

Text-based knowledge discovery: search and mining of life-sciences documents • Review article

Drug Discovery Today, Volume 7, Issue 11, May 2002, Pages S89-S98 | Mack, R.; Hehenberger, M.
20/10/2009

Understanding autoimmune disease: new targets for drug discovery • Review article

Drug Discovery Today, Volume 14, Issue 19-20, October 2009, Pages 926-934 | Balague, C.; Kunkel, S.L.; Godessart, N.
26/02/2010

New promising drug targets in cancer- and metastasis-initiating cells • Review article

Drug Discovery Today, Volume 15, Issue 9-10, May 2010, Pages 354-364 | Mimeault, M.; Batra, S.K.
26/08/2010

Evolving molecules using multi-objective optimization: applying to ADME/Tox • Review article

Drug Discovery Today, Volume 15, Issue 11-12, June 2010, Pages 451-460 | Ekins, S.; Honeycutt, J.D.; Metz, J.T.
26/08/2010

Natural products in drug discovery • Review article

Drug Discovery Today, Volume 13, Issue 19-20, October 2008, Pages 894-901 | Harvey, A.L.
20/10/2009

Brain drug targeting: a computational approach for overcoming blood-brain barrier • Review article

Drug Discovery Today, Volume 14, Issue 21-22, November 2009, Pages 1030-1036 | Mehdipour, A.R.; Hamidi, M.
26/02/2010

The changing landscape of cancer drug discovery: a challenge to the medicinal chemist of tomorrow • Review article

Drug Discovery Today, Volume 14, Issue 21-22, November 2009, Pages 1045-1050 | Pors, K.; Goldberg, F.W.; Leamon, C.P.; Rigby, A.C.; Snyder, S.A.; Falconer, R.A.
26/02/2010

The nasty surprise of a complex drugdrug interaction • Review article

Drug Discovery Today, Volume 15, Issue 9-10, May 2010, Pages 391-395 | Bode, C.
26/08/2010

Navigating structure-activity landscapes • Review article

Drug Discovery Today, Volume 14, Issue 13-14, Pages 698-705 | Bajorath, J.; Peltason, L.; Wawer, M.; Guha, R.; Lajiness, M.S.; Van Drie, J.H.
01/12/2009

The impact of synthetic biology on drug discovery • Review article

Drug Discovery Today, Volume 14, Issue 19-20, October 2009, Pages 956-963 | Weber, W.; Fussenegger, M.
26/02/2010

Histone acetyl transferases as emerging drug targets • Review article

Drug Discovery Today, Volume 14, Issue 19-20, October 2009, Pages 942-948 | Dekker, F.J.; Haisma, H.J.
26/02/2010

Medicinal chemistry strategies in follow-on drug discovery • Review article

Drug Discovery Today, Volume 14, Issue 9-10, May 2009, Pages 516-522 | Zhao, H.; Guo, Z.
20/10/2009

Proton pump inhibitors: actions and reactions • Review article

Drug Discovery Today, Volume 14, Issue 13-14, Pages 647-660 | Mullin, J.M.; Gabello, M.; Murray, L.J.; Farrell, C.P.; Bellows, J.; Wolov, K.R.; Kearney, K.R.; Rudolph, D.; Thornton, J.J.
01/12/2009

Visualizing the drug target landscape • Review article

Drug Discovery Today, Volume 15, Issue 1-2, January 2010, Pages 3-15 | Campbell, S.J.; Gaulton, A.; Marshall, J.; Bichko, D.; Martin, S.; Brouwer, C.; Harland, L.
26/05/2010

Does R&D pay? • Review article

Drug Discovery Today, Volume 15, Issue 5-6, March 2010, Pages 230-234 | Cavalla, D.; Minhas, R.
26/05/2010

Dendrimer-based drug and imaging conjugates: design considerations for nanomedical applications • Review article

Drug Discovery Today, Volume 15, Issue 5-6, March 2010, Pages 171-185 | Menjoge, A.R.; Kannan, R.M.; Tomalia, D.A.
26/08/2010

Developments in fluorescent probes for receptor research • Review article

Drug Discovery Today, Volume 14, Issue 13-14, Pages 706-712 | Leopoldo, M.; Lacivita, E.; Berardi, F.; Perrone, R.
01/12/2009

Synthetic therapeutic peptides: science and market • Review article

Drug Discovery Today, Volume 15, Issue 1-2, January 2010, Pages 40-56 | Vlieghe, P.; Lisowski, V.; Martinez, J.; Khrestchatisky, M.
26/05/2010

Molecular fields in drug discovery: getting old or reaching maturity? • Review article

Drug Discovery Today, Volume 15, Issue 1-2, January 2010, Pages 23-32 | Cross, S.; Cruciani, G.
26/05/2010

Assessing the bioequivalence of biosimilars • Review article

Drug Discovery Today, Volume 14, Issue 9-10, May 2009, Pages 495-499 | Schellekens, H.
20/10/2009

Drug discovery: new models for industry-academic partnerships • Review article

Drug Discovery Today, Volume 14, Issue 1-2, Pages 95-101 | Tralau-Stewart, C.J.; Wyatt, C.A.; Kleyn, D.E.; Ayad, A.
01/12/2009