Drug Delivery: enabling technology for discovery and development Date: 7 December 2011, 8am PT, 11am ET, 4pm GMT Duration: 1 hours

The integration of pharmacodynamic and pharmacokinetic parameters in non clinical pharmacology studies is a key aspect in drug discovery for efficacy and safety assessment, in the particular for the translation from the non clinical to the clinical field. Modeling the profile of plasma exposure achieved with the intended therapeutic route often requires the use of intravenous infusion. In addition, in most cases infusion parameters (infusion rate, volume, duration and sequences) need to be customized to achieve the appropriate pattern of plasma drug exposure. When pharmacodynamic parameters are recorded by telemetry, the use of implantable pumps rather than external pumps is necessary to preserve the improvement in physiological data recording offered by telemetry.

Enhancing productivity and accuracy in drug metabolism studies with the latest Orbitrap technology Date: 6 December 2011, 8am PT, 11am ET, 4pm GMT Duration: 1 hours

This webinar explores how productivity and accuracy in drug metabolism studies can be improved by employing the latest advancement in Orbitrap technology in pharmaceutical science and related industries

Part 2: How has HR-MS technology fundamentally changed the way we study drug biotransformation and disposition? Date: 25 August 2011, 10.00am Shanghai Time Duration: 1 hours

AB SCIEX is proud to present the 2nd installment of a Global 4-Part Live Webinar Series exploring novel and dynamic workflows for Metabolite Identification & Drug Metabolism solutions as it pertains to the 4 main stages of the drug discovery and development paradigm, Lead Discovery, Late Stage Discovery, Early Development and Late Stage Development. Part 2 of this webinar series will focus on how HRMS technology has fundamentally changed the way metabolite biotransformations are investigated in Lead Discovery.

Industrialized Global Metabolite ID Solutions in the New Drug Discovery and Development Paradigm. Date: 20 April 2011, 11:00 AM EST/ 16:00 GMT Duration: 1 hours

AB SCIEX is proud to present the initial installment of a Global 4-Part Live Webinar Series exploring novel and dynamic workflows for Metabolite Identification & Drug Metabolism solutions as it pertains to the 4 main stages of the drug discovery and development paradigm, Lead Discovery, Late Stage Discovery, Early Development and Late Stage Development. Part 1 of this webinar series will focus on uniquely intelligent HRMS workflows for metabolite ID in Lead Discovery.

The renaissance of clinical biochemistry: Diagnostic biomarker discovery by targeted metabolomics Date: 25 March 2010, 1pm Eastern Daylight Time Duration: 1 hours

Metabolomics, i.e. the systematic identification and quantitation of marker metabolites in a given compartment, cell, tissue or body fluid, is increasingly recognized as the most relevant approach to depicting the functional end-points of physiological and pathophysiological processes. Yet, a reliable and standardized technology platform rendering metabolomics applicable to routine diagnostics has not been in place so far.

Metabolomics, a Novel Tool for Understanding the Early-Stage Mechanistic Underpinnings of Drug Action and Safety. Date: 30 June 2009, Duration: 1 hours

In association with Matabolon. This presentation demonstrated the utility of metabolomics in drug safety research through a case study done in collaboration with Teva Pharmaceutical Industries Ltd.