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Latest News
CRT and Bayer Schering Pharma to investigate gynaecological and oncological diseases
CRT and Bayer Schering Pharma to investigate gynaecological and oncological diseases
Cancer Research Technology has signed an agreement with Bayer Schering Pharma AG, Germany, to evaluate new leptin antagonist peptides as potential experimental treatments, initially in the area of gynaecological diseases, including cancer.
CRT and ValiRx sign prostate cancer treatment deal
Cancer Research Technology has signed a deal to provide biotech company ValiRx PLC with the global rights to develop a promising compound to treat hormone-resistant prostate cancer.
Collaboration discovers selective inhibitors against PI3Ka
Numerate and Intellikine have announced the successful conclusion of their research collaboration to discover novel small-molecule compounds targeting the PI3K/mTOR signaling pathway.
Cable appoints new Chief Executive for MRC
Secretary of State for Business, Innovation and Skills Vince Cable today announced the appointment of Sir John Savill as Chief Executive and Deputy Chair of the Medical Research Council.
Collaboration to establish Tokyo Biomarker Research Center
Thermo Fisher Scientific has announced a landmark collaboration that aims to introduce mass-spectrometry-based workflows and technologies into Japan to advance personalized medicine and healthcare.
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Podcasts
Evotec strengthens and expands its Alliance Business
Dr Mark Ashton is Executive Vice President, Business Development of Evotec and is responsible for Evotec's commercial and partnering activities. Prior to assuming responsibility for Business Development in 2005, Dr Ashton held a number of positions within Operations at Evotec: He joined the Company in 1995 as one of the initial employees of the Discovery Division, becoming Department Manager in 2001, Director of Chemistry Services in 2002 and taking over responsibility for Evotec's Discovery Services Division in 2004, where he had responsibility for Evotec's screening, parallel synthesis and medicinal chemistry operations. During his time at Evotec, Dr Ashton has managed a wide range of pharmaceutical and biotechnology related projects, including medicinal chemistry projects, design and synthesis of screening libraries and technology transfer projects and has been involved in the progression of a number of drug candidates into the clinic in numerous therapeutic areas. Dr Ashton has authored and co-authored a number of peer reviewed papers, articles and book chapters in addition to being named on a number of pharmaceutical patents. He is trained as a medicinal chemist. Prior to joining Evotec, Dr Ashton also had spells at ICI Pharmaceuticals and Organon Laboratories. Mark Whittaker is Senior Vice President Drug Discovery at Evotec where he manages a large drug discovery collaboration and the groups of computational chemistry and structural biology. Before joining Evotec in 2001, Mark spent 13 years at British Biotech Pharmaceuticals where he led a number of medicinal chemistry programmes and was latterly Director of Chemistry. At British Biotech, Mark contributed to the discovery and development of six compounds that have progressed into human clinical trials. Before his career at British Biotech, Mark carried out post-doctoral research at the University of Oxford and at York University, Toronto and obtained a D. Phil in Chemistry from the University of York.
The Ubiquitin Story
In this podcast interview with Drug Discovery Today, Nobel Prize winner Professor Aaron Ciechanover will talk about his career, his Nobel Prize-winning discovery of the UPS, and the extraordinary opportunities and challenges for drug discovery in this area.
Califf, Behrman and Kramer discuss the Clinical Trials Transformation Initiative.
Download the Califf, Behrman and Kramer podcast as an mp3 file
Dr Brent Vose outlines AstraZeneca's oncology pipeline.
Download the Dr. Brent Vose podcast as an mp3 file
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Webinars
The renaissance of clinical biochemistry: Diagnostic biomarker discovery by targeted metabolomics
Metabolomics, i.e. the systematic identification and quantitation of marker metabolites in a given compartment, cell, tissue or body fluid, is increasingly recognized as the most relevant approach to depicting the functional end-points of physiological and pathophysiological processes. Yet, a reliable and standardized technology platform rendering metabolomics applicable to routine diagnostics has not been in place so far.
Aequorin Bioluminescence Assays – a paradigm shift?
Metabolomics, a Novel Tool for Understanding the Early-Stage Mechanistic Underpinnings of Drug Action and Safety.
In association with Matabolon. This presentation demonstrated the utility of metabolomics in drug safety research through a case study done in collaboration with Teva Pharmaceutical Industries Ltd.
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Downloads
The shrinking of the knowledge base – what is the impact of this on the speed and security of drug development?
Paul Branthwaite discusses the implication of reducing the Pharmaceutical industry knowledge base as a result of mergers, acquisitions and a drive to reduce cost base. He specificaly deals with the impact of these changes on the ability to produce innovative pharmaceuticals and the time required so to do.
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25 Hottest Articles
Pharmacophore modeling and applications in drug discovery: challenges and recent advances • Review article
Drug Discovery Today, Volume 15, Issue 11-12, June 2010, Pages 444-450 | Yang, S.Y.
The road ahead for large pharma: long-term science and innovation • Editorial
Drug Discovery Today, Volume 14, Issue 9-10, May 2009, Pages 439-441 | Lundberg, J.M.; Reilly, C.
The growing impact of click chemistry on drug discovery • Review article
Drug Discovery Today, Volume 8, Issue 24, December 2003, Pages 1128-1137 | Kolb, H.C.; Sharpless, K.B.
Drug discovery chemistry: a primer for the non-specialist • Review article
Drug Discovery Today, Volume 14, Issue 15-16, August 2009, Pages 731-744 | Jordan, A.M.; Roughley, S.D.
Text-based knowledge discovery: search and mining of life-sciences documents • Review article
Drug Discovery Today, Volume 7, Issue 11, May 2002, Pages S89-S98 | Mack, R.; Hehenberger, M.
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