Drug Discovery Today Interactive Webinar: Register Now
In Association with: 
Metabolomics: A Novel Tool for Understanding the Early-Stage Mechanistic Underpinnings of Drug Action and Safety
Date: Tuesday 30th June 2009
Time: 4pm BST, 11am EST
Duration: 60 minutes
Registration is free.
Reserve your place now.
With increased regulatory scrutiny, understanding the mechanistic underpinnings of drug action and safety has become paramount. Earlier information on potential drug safety issues is required before deciding which compounds to take into the clinic. Global biochemical profiling, provides unparalleled insight into the mechanistic action of drugs. The simultaneous analysis of hundreds of biochemicals enables the identification of both on-target and off-target effects – many changes seen within hours of dosing, providing early-stage indication of safety issues.
This presentation will discuss a study designed to help researchers to identify a panel of biomarkers that provide a non-invasive method to detect kidney injury long before the onset of histopathological kidney damage*. The research team was able to extract, identify, and quantify biochemicals in a non-targeted and global analytical approach.
* Discovery of Metabolomics Biomarkers for Early Detection of Nephrotoxicity, Toxicologic Pathology, Vol. 37, No. 3, 280-292, (2009)
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