Drug Discovery Today - the magazine for the drug discovery professional: authoritative reviews and expert opinion; industry focused and peer reviewed.

Latest News

Sphere Fluidics updates brand identity to align with ambitious, global commercial growth strategy
New branding reflects customer-centric approach and showcases pioneering, single cell analysis technology Rebrand follows a period of significant growth for the Company, including key leadership team appointments, state-of-the-art facility expansion, and new scientific partnerships
Seqera Labs partners with Genomics England to enhance genomic research capabilities
BARCELONA/LONDON, 25.05.23: Seqera Labs, the leading provider of secure workflow orchestration software in the life sciences sector, has partnered with Genomics England, the government-owned company that launched the 100,000 Genomes Project in partnership with the NHS. The new collaboration between Seqera Labs and Genomics England will enable whole genome analysis to be carried out at a larger scale with greater efficiency, helping more patients benefit from genomic healthcare and equipping researchers with extra data to find the causes of disease and develop new treatments.
Touchlight completes expansion, creating one of the world’s largest DNA manufacturing facilities in London, UK
The Facility will have capacity that exceeds today’s global plasmid DNA demand and can enable commercialisation of genetic medicines. Transformation of Grade II-listed Victorian waterworks on the River Thames in Hampton, London. Supplying many of the top biopharmaceutical companies in the world to dramatically enhance their ability to develop genetic medicines.Expansion follows recent acceptance of a Drug Master File and first investigational new drug application using doggybone DNA.
Connect in Pharma launches partnerships for global health innovation
Sciad Newswire / Connect in Pharma announce today that for every visitor to the 2023 Geneva-based event, five Swiss francs will be donated to Global Health Security (GHS) Fund, a non-profit organisation driving local innovation and global programming to address threats to health security.
Pharmaceutical Industry Needs More Cross-Sector Collaboration
The newly announced agenda for Connect in Pharma sends a strong message for more cross-sector collaboration. Technology gurus, consultancy experts and motivational speakers from a wide range of industries are calling for a new, modern era of pharmaceutical packaging and manufacturing that utilises high-tech and innovative thinking from other industries.

Podcasts

Evotec strengthens and expands its Alliance Business
Dr Mark Ashton is Executive Vice President, Business Development of Evotec and is responsible for Evotec's commercial and partnering activities. Mark Whittaker is Senior Vice President Drug Discovery at Evotec where he manages a large drug discovery collaboration and the groups of computational chemistry and structural biology.
The Ubiquitin Story
In this podcast interview with Drug Discovery Today, Nobel Prize winner Professor Aaron Ciechanover will talk about his career, his Nobel Prize-winning discovery of the UPS, and the extraordinary opportunities and challenges for drug discovery in this area.
Califf, Behrman and Kramer discuss the Clinical Trials Transformation Initiative.
Download the Califf, Behrman and Kramer podcast as an mp3 file
Dr Brent Vose outlines AstraZeneca's oncology pipeline.
Download the Dr. Brent Vose podcast as an mp3 file

Webinars

The Promise of Epigenetics in Early Stage Drug Discovery
Epigenetic targets are exciting to drug discovery scientists because they hold great potential across a wide spectrum of therapeutic areas. The field of epigenetics focuses on the investigation of enzymes that alter gene expression through modification of their target substrates, usually through the addition or removal of methyl or acetyl groups. High-throughput assays to identify agents capable of modifying the action of such enzyme targets has, in the past, proven to be challenging due to the relatively small molecular alterations in addition to the possibility of sequential modifications, leading to multiple end products. As such, high-throughput bioassays that allow the direct, concurrent quantification of multiple modification states are attractive. The RapidFire platform enables high-throughput mass spectrometric analysis of native molecules from in vitro reactions by performing on-line desalting in seconds, as opposed to HPLC, which requires minutes. Moreover, the RapidFire system can be connected to any mass spectrometer providing unparalleled versatility in reaction detection.
Integrated Quant / Qual for In-vivo Discovery Bioanalysis using Hybrid Quadrupole-Time-of-Flight Mass Spectrometry
Ultra high performance liquid chromatography (UHPLC) coupled with orthogonal acceleration hybrid quadrupole-time-of-flight (QqTOF) mass spectrometry is an emerging technique offering new strategies for the efficient screening of new chemical entities (NCE) and related molecules at the early discovery stage within the pharmaceutical industry.
Drug Delivery: enabling technology for discovery and development
The integration of pharmacodynamic and pharmacokinetic parameters in non clinical pharmacology studies is a key aspect in drug discovery for efficacy and safety assessment, in the particular for the translation from the non clinical to the clinical field. Modeling the profile of plasma exposure achieved with the intended therapeutic route often requires the use of intravenous infusion. In addition, in most cases infusion parameters (infusion rate, volume, duration and sequences) need to be customized to achieve the appropriate pattern of plasma drug exposure. When pharmacodynamic parameters are recorded by telemetry, the use of implantable pumps rather than external pumps is necessary to preserve the improvement in physiological data recording offered by telemetry.
Part 2: How has HR-MS technology fundamentally changed the way we study drug biotransformation and disposition?
AB SCIEX is proud to present the 2nd installment of a Global 4-Part Live Webinar Series exploring novel and dynamic workflows for Metabolite Identification & Drug Metabolism solutions as it pertains to the 4 main stages of the drug discovery and development paradigm, Lead Discovery, Late Stage Discovery, Early Development and Late Stage Development. Part 2 of this webinar series will focus on how HRMS technology has fundamentally changed the way metabolite biotransformations are investigated in Lead Discovery.

Features

Peptide therapeutics: current statusand future directions
Here, the authors discuss the current status, strengths, and weaknesses of peptides as medicines and the emerging new opportunities in peptide drug design and development.
Getting the most out of your IP – patent management along its life cycle
We discover that successful patent portfolio management is rooted in managing the patents along their life cycles.
What makes a good drug target? What makes a good drug target?
In this article, Isabella Gashaw , Peter Ellinghaus, Anette Sommer and Khusru Asadullah discuss those factors that differentiate good drug targets from poor or the unusable.
Drug discovery in the next decade:innovation needed ASAP
The pharmaceutical sector, a cornerstone of the healthcare industry, is undergoing dramaticchange, primarily caused by reduced output of new medicines from research and development(R&D) laboratories, drug pricing pressures, stricter regulatory environments and the overallcurrent economic downturn. This makes demands of all pharmaceutical companies to find better ways to increase their output of new drugs, through innovation, to both treat patients and meet their shareholders’ expectations.

Downloads

Emerging trends in pulmonary delivery of biopharmaceuticals
Pulmonary delivery of biopharmaceuticals is a niche area of the current pharmaceutical market holding immense scope for drug discovery and development. To combat the limitation-driven conventional treatments, pulmonary administration of biopharmaceuticals has navigated remarkable change in targeted drug delivery
Engineering nanoparticle therapeutics for impaired wound healing in diabetes
We focus on emerging nanotherapeutics capable of addressing the pathophysiology of chronic wounds in diabetes to better manage the impaired healing that current clinical treatments fail to address.
Stimuli sensitive drug delivery systems for site specific antibiotic release
This review provides key insights into current challenges and future directions of exogenous and endogenous stimuli-sensitive targeted and on-demand release of therapeutic doses of antibiotics both cost-effectively and safely.
Medicinal Chemistry Strategies for the Discovery of Antivirals Targeting to Influenza Virus PB2 Cap-binding Domain
This review covers the strategies and challenges in the discovery and development of small-molecule inhibitors for the influenza A PB2 cap-binding domain.
Machine Learning to Design Antimicrobial Combinations Promises and Pitfalls
We discuss strategies for applying machine learning methods to identify synergistic drug combinations from millions of candidates using information on the compound, pathogen and disease environment.

25 Hottest Articles

Peptide therapeutics: current status and future directions • Review article
Drug Discovery Today, Volume 20, Issue 1, Pages 122-128 | Fosgerau, K.; Hoffmann, T.
Bispecific antibodies • Review article
Drug Discovery Today, Volume 20, Issue 7, Pages 838-847 | Kontermann, R.E.; Brinkmann, U.
Designing novel building blocks is an overlooked strategy to improve compound quality • Review article
Drug Discovery Today, Volume 20, Issue 1, January 2015, Pages 11-17 | Goldberg, F.W.; Kettle, J.G.; Kogej, T.; Perry, M.W.D.; Tomkinson, N.P.
The road ahead for large pharma: long-term science and innovation • Editorial
Drug Discovery Today, Volume 14, Issue 9-10, May 2009, Pages 439-441 | Lundberg, J.M.; Reilly, C.
The impact of aromatic ring count on compound developability - are too many aromatic rings a liability in drug design? • Review article
Drug Discovery Today, Volume 14, Issue 21-22, November 2009, Pages 1011-1020 | Ritchie, T.J.; Macdonald, S.J.F.

Latest News

Podcasts

Webinars

Features

Downloads

25 Hottest Articles

There is a US version of this site available...