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An enzyme enigma discovered in the abyss An enzyme enigma discovered in the abyss

Scientists at the Universities of Bristol and Newcastle have uncovered the secret of the ‘Mona Lisa of chemical reactions’ – in a bacterium that lives at the bottom of the Pacific Ocean.

Genetic Variations that Boost PKC Enzyme Contribute to Alzheimer’s Disease Genetic Variations that Boost PKC Enzyme Contribute to Alzheimer’s Disease

PKC alpha is required for pathological consequences of amyloid beta plaques; mutations that enhance its activity found in patients with the disease

TSRI Team Streamlines Biomedical Research by Making Genetic Data Easier to Search TSRI Team Streamlines Biomedical Research by Making Genetic Data Easier to Search

Call them professional “data wranglers.”

Scripps Florida Scientists Design Potent Therapeutic ‘Warheads’ That Target Cancer Cells Scripps Florida Scientists Design Potent Therapeutic ‘Warheads’ That Target Cancer Cells

In a pair of related studies, chemists from the Florida campus of The Scripps Research Institute (TSRI) have identified and designed dozens of molecular “warheads” that not only can detect a key biomarker of cancer, but also could be developed into a potent new class of drug candidates for a range of diseases.

Loss of chromosome 8p governs tumor suppression and drug response Loss of chromosome 8p governs tumor suppression and drug response

In a typical cancer cell, up to one-quarter of the genome is lost due to large chromosomal deletions, while the concomitant loss of hundreds of genes creates vulnerabilities that are impossible to reveal through the study of individual genes. Prof. Anna Sablina and her team at VIB/KU Leuven optimized a workflow for the generation of cell lines with targeted chromosomal deletions.

The Current issue of “The view from here” presents Precompetitive intelligence. The Current issue of “The view from here” presents Precompetitive intelligence.

The topic of this month’s newsletter from Drug Discovery Today is “Precompetitive intelligence”.

TSRI Scientists Find Root Cause of Appetite Loss During Illness TSRI Scientists Find Root Cause of Appetite Loss During Illness

The Discovery Opens the Door to New Therapies Influencing Appetite and WeightLoss of appetite during illness is a common and potentially debilitating phenomenon—in cancer patients, especially, it can even shorten lifespan.Now scientists at The Scripps Research Institute (TSRI) have discovered how an immune system molecule hijacks a brain circuit and reduces appetite. Their research points to potential targets for treating loss of appetite and restoring a patient’s strength.