Drug discovery in the next decade:innovation needed ASAP Drug discovery in the next decade:innovation needed ASAP

The pharmaceutical sector, a cornerstone of the healthcare industry, is undergoing dramaticchange, primarily caused by reduced output of new medicines from research and development(R&D) laboratories, drug pricing pressures, stricter regulatory environments and the overallcurrent economic downturn. This makes demands of all pharmaceutical companies to find better ways to increase their output of new drugs, through innovation, to both treat patients and meet their shareholders’ expectations.
05 January 2012

Learning lessons from drugs that haverecently entered the market Learning lessons from drugs that haverecently entered the market

In this article, the most downloaded of Q2 2011, Simon Teague outlines that the key determinants for success in drug discovery can be defined by studying recently launched drugs.
05 January 2012

The graphical representation of ADME-related molecule properties for medicinal chemists The graphical representation of ADME-related molecule properties for medicinal chemists

In this article, the most downloaded of Q1 2011, Timothy J. Ritchie, Peter Ertl and Richard Lewis review various approaches that have been used to represent molecule properties graphically in the context of oral ‘drug likeness’, with the goal of improving the decision making of medicinal chemists during the drug discovery process.
05 January 2012

Cancer nanotechnology: application of nanotechnology in cancer therapy Cancer nanotechnology: application of nanotechnology in cancer therapy

In this article, the most downloaded article of Q4 2010, Ranjita Misra, Sarbari Acharya and Sanjeeb K. Sahoo discuss the applications of nanotechnology to the treatment of cancer
16 February 2011

Getting physical in drug discovery: a contemporary perspective on solubility and hydrophobicity Getting physical in drug discovery: a contemporary perspective on solubility and hydrophobicity

The physical properties of drug molecules are frequently identified as a shortcoming of drugs in development. This article, the most highly-downloaded of Q3 2010, proposes a novel approach to the prediction of water solubility
01 February 2011

Pharmacophore modeling and applications in drug discovery: challenges and recent advances Pharmacophore modeling and applications in drug discovery: challenges and recent advances

The most downloaded article from Drug Discovery Today in Q2 2010 was by Sheng-Yong Yang and deals with the application of pharmacophore modeling to drug discovery.
01 February 2011

Visualizing the drug target landscape Visualizing the drug target landscape

This article, by Stephen J. Campbell, Anna Gaulton, Jason Marshall, Dmitri Bichko, Sid Martin, Cory Brouwer1 and Lee Harland was the most downloaded article of Q1 2010. It deals with tools to integrate biological, chemical and clinical resources.
01 February 2011

The impact of aromatic ring count on compound developability – are too many aromatic rings a liability in drug design? The impact of aromatic ring count on compound developability – are too many aromatic rings a liability in drug design?

The content of the most downloaded article in Q4 2009 deals with the impact of the number of aromatic rings on the ability to deliver quality compounds for drug development. This information and analysis is clearly highly important and directly relevant to the day-to-day work of the medicinal chemist.
01 February 2011

Transforming fragments into candidates: small becomes big in medicinal chemistry Transforming fragments into candidates: small becomes big in medicinal chemistry

Again, medicinal chemistry features highly in our "Most downloaded" spot. This time we feature the extremely hot topic of fragment-based drug discovery, from some of the most influential experts, based in the Netherlands and the UK
01 February 2011

Medicinal chemistry strategies in follow-on drug discovery Medicinal chemistry strategies in follow-on drug discovery

This article was the most downloaded article in the period Q2 2009. A common theme appears with many of our most popular articles in that they frequently relate to medicinal chemistry strategy or practice. I hope that you enjoy this article.
01 February 2011