Human pluripotent stem cell-derived cardiovascular progenitors for heart regeneration

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In this article Lui et al. discuss the innate capacity for cardiac regeneration in zebrafish, the types of progenitors driving development in the mammalian heart and how to empower cardiac progenitor cells or myocytes derived from human pluripotent stem cells to survive, engraft and improve function in the hostile microenvironment of the post-ischemic heart.

Furthermore, they discuss the relevant aspects of human cardiogenesis and how heart regeneration can be promoted by the use of human PSCs (hPSCs).

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