Shifting from the single to the multitarget paradigm in drug discovery

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Increasing evidence that several drug compounds exert their effects through interactions with multiple targets is boosting the development of research fields that challenge the data reductionism approach.

In this article, Jose´ L. Medina-Franco, Marc A. Giulianotti,Gregory S. Welmakerand Richard A. Houghten review and discuss the concepts of drug repurposing, polypharmacology, chemogenomics, phenotypic screening and high-throughput in vivo testing of mixture-based libraries in an integrated manner. These research fields offer alternatives to the current paradigm of drug discovery, from a one target–one drug model to a multiple-target approach.

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