Low-dose metronomic chemotherapy: from past experience to new paradigms in the treatment of cancer

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This article summarizes preclinical and clinicalexperience with LDM chemotherapy, emphasizing the potential contribution of this new treatmentmodality to future paradigms in the systemic treatment of patients with cancer.

Low-dose metronomic (LDM) chemotherapy represents an emerging concept in the treatment of cancer. Directed against tumor cells and other types of cells, such as endothelial and immune cells, this treatment regimen alters the tumor microenvironment and suppresses innate features which support tumor growth. Ongoing Phase III clinical studies explore various applications of LDM chemotherapy, mostly combined with other anticancer agents, to act as complementary treatments to conventional maximum tolerated dose (MTD) chemotherapy.

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