Phenotypic screening the future of antibody discovery

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Drug screening based on phenotype, rather than target, is currently an undervalued approach for antibody discovery. In this review, we find significant opportunities in accessing novel target space through phenotypic antibody discovery

 Most antibody therapeutics have been isolated from high throughput target-based screening. However, as the number of validated targets diminishes and the target space becomes increasingly competitive, alternative strategies, such as phenotypic screening, are gaining momentum. Here, we review successful phenotypic screens, including those used to isolate antibodies against cancer and infectious agents. We also consider exciting advances in the expression and phenotypic screening of antibody repertoires in single cell autocrine systems. As technologies continue to develop, we believe that antibody phenotypic screening will increase further in popularity and has the potential to provide the next generation of

therapeutic antibodies.

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