Industrial medicinal chemistry insights neuroscience hit generation at Janssen

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Modern medicinal chemistry impacts drug discovery in many ways beyond just optimization of clinical candidates. Here we describe the formation and work of a small team dedicated to hit and lead generation with novel methods inside Janssen.

The role of medicinal chemistry has changed over the past 10 years. Chemistry had become one step in a process; funneling the output of highthroughput screening (HTS) on to the next stage. The goal to identify the ideal clinical compound remains, but the means to achieve this have changed. Modern medicinal chemistry is responsible for integrating innovation throughout early drug discovery, including new screening paradigms, computational approaches, novel synthetic chemistry, gene family screening, investigating routes of delivery, and so on. In this Foundation Review, we show how a successful medicinal chemistry team has a broad impact and requires multidisciplinary expertise in these areas.

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