Pharmaceutical nanocrystals production by wet milling and applications

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This review outlines the advantages, stabilization, and production of drug nanocrystals with an emphasis on wet milling. Covering their pharmaceutical applications, it reveals why nanocrystals are an industrially feasible formulation strategy.

 Nanocrystals are regarded as an important nanoformulation approach

exhibiting advantages of increased dissolution and saturation solubility
with chemical stability and low toxicity. Nanocrystals are produced in the
form of nanosuspensions using top-down (e.g., wet milling or high
pressure homogenization) and bottom-up methods (e.g., antisolvent
precipitation). Wet milling is a scalable method applicable to drugs with
different physicochemical and mechanical properties. Nanocrystallinebased
formulations, either as liquid nanosuspensions or after downstream
processing to solid dosage forms, have been developed as drug delivery
systems for various routes of administration (i.e., oral, parenteral,
pulmonary, ocular, and dermal). In this review, we summarize and discuss
the features, preparation methods, and therapeutic applications of
pharmaceutical nanocrystals, highlighting their universality as a
formulation approach for poorly soluble drugs.

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