Increased Building Block Access Through Collaboration

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the authors discuss the benefits of collaboration in the access of building blocks at the precompetitive stage

 Fluorine can impact potency, selectivity and ADME of medicinal chemistry analogs.


Fluorinated building blocks (FBB) greatly enable fluorinated analog preparation.

Some vendor-listed FBB are expensive because many have not been synthesized.

A vendor–pharma Buying Group was created to share costs and reduce FBB prices.

The details of the Buying Group formation, FBB usage and conclusions are presented.



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