Fluorine can impact potency, selectivity and ADME of medicinal chemistry analogs.
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Fluorinated building blocks (FBB) greatly enable fluorinated analog preparation.
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Some vendor-listed FBB are expensive because many have not been synthesized.
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A vendor–pharma Buying Group was created to share costs and reduce FBB prices.
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The details of the Buying Group formation, FBB usage and conclusions are presented.