Drug delivery to retinal photoreceptors

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Routes of administration to retinal photoreceptors. The blood–retinal barrier as a challenge for photoreceptor drug delivery. Review of nanoparticle drug delivery systems used for intraocular applications. Perspectives for topical drug delivery to the retina.

The photoreceptors of the retina are afflicted by diseases that still often lack satisfactory treatment options. Although suitable drugs might be available in some cases, the delivery of these compounds into the eye and across the blood–retinal barrier remains a significant challenge for therapy development. Here, we review the routes of drug administration to the retina and highlight different options for drug delivery to the photoreceptor cells.

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