New generation drugs for treatment of multiple myeloma

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This review will examine the efficacy and pro-thrombotic effects of MM therapies.

 • MM is treated with cyclophosphamide plus steroid with PI or IMID or anti-CD38.

• MM therapy combinations increase thrombotic risk.
• MM therapy can induce thrombocytopenia thereby increasing bleeding risk.
• Detailed mechanisms of the prothrombotic effects of MM treatment are unclear.
• Antiplatelet and anticoagulant drugs in combination treatments require further evaluation.

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