Could PROTACs Protect Us From COVID-19

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In this article, we analyze specific requirements that define potent PROteolysis TArgeting Chimeras (PROTACs), and discuss their potential therapeutic power to target SARS-CoV-2 for both the treatment and prevention of COVID-19.

The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in the current coronavirus disease 2019 (COVID-19) pandemic, which has infected over 22 million people worldwide as of mid-August 2020. Effective treatment is urgently needed and in response multiple traditional and default approaches are being actively pursued by pharmaceutical companies and academic institutions in numerous countries. These efforts include development of small molecules inhibitors, the repurposing of existing drugs, and the development of new vaccines. However, the high mortality of COVID-19 and its uncontrolled spread amongst the population demands more innovative thinking and novel therapeutic approaches to treat the disease.

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