Epigenetic regulation in macrophage migration inhibitory factor (MIF) mediated signaling in cancer and inflammation

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Macrophage migration inhibitory factor (MIF) plays a crucial role in cancer and inflammatory diseases. Epigenetic mechanisms are involved in MIF-mediated signaling. Histone deacetylase inhibitors (HDACi) and non-coding RNAs are important regulators of MIF gene expression. Epigenetic mechanisms in MIF- and D-dopachrome tautomerase (D-DT)-mediated signaling are underexplored.

 Epigenetic mechanisms are important for the regular development and maintenance of the tissue-specific expression of cytokine genes. One of the crucial cytokines involved in cancer and inflammation is macrophage migration inhibitory factor (MIF), which triggers the mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K) signaling pathways by binding to CD74 and other receptors. Altered expression of this cytokine and altered activity states of the connected pathways are linked to inflammatory disease and cancer. Therapeutic strategies based on epigenetic mechanisms have the potential to regulate MIF-mediated signaling in cancer and inflammation.

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