Engineering nanoparticle therapeutics for impaired wound healing in diabetes

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We focus on emerging nanotherapeutics capable of addressing the pathophysiology of chronic wounds in diabetes to better manage the impaired healing that current clinical treatments fail to address.

Diabetes mellitus is a chronic disease characterized by increased blood glucose levels, leading to damage of the nerves blood vessels, subsequently manifesting as organ failures, wounds, or ulcerations. Wounds in patients with diabetes are further complicated because of reduced cytokine responses, infection, poor vascularization, and delayed healing processes. Surface-functionalized and bioengineered

nanoparticles (NPs) have recently gained attention as emerging treatment modalities for wound healing in diabetes. Here, we review emerging therapeutic NPs to treat diabetic wounds and highlight their discrete delivery mechanisms and sites of action. We further critically assess the current challenges of these nanoengineered materials for successful clinical translation and discuss their
potential for growth in the clinical marketplace.

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