Downloads

Inflammation, stress and depression: an exploration of ketamine’s therapeutic profile


Download Type: External Link

This review investigates the role of inflammation in chronic stress and depression, as well as how the rapid-acting antidepressant ketamine can exert some of its therapeutic effects via anti-inflammatory mechanisms.

Well-established animal models of depression have described a proximal relationship between stress and central nervous system (CNS) inflammation – a relationship mirrored in the peripheral inflammatory biomarkers of individuals with depression. Evidence also suggests that stress-induced proinflammatory states can contribute to the neurobiology of treatment-resistant depression. Interestingly, ketamine, a rapid-acting antidepressant, can partially exert its therapeutic effects via anti-inflammatory actions on the hypothalamic-pituitary-adrenal (HPA) axis, the kynurenine pathway or by cytokine suppression. Further investigations into the relationship between ketamine, inflammation and stress could provide insight into ketamine’s unique therapeutic mechanisms and stimulate efforts to develop rapid-acting, anti-inflammatory-based antidepressants.


 [A1]AQ: Owing to its ambiguity it is DDT housestyle to avoid the word may and use can, could or might instead. Please check that I have used the correct alternative in each instance

Share this download

More services