Epigenetic therapies for non-oncology indications

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Chronic and degenerative disorders are a major, and growing, human health burden, and current treatments are in many cases inadequate or very expensive. Epigenetic therapies are attractive options for treating such disorders because they manipulate the processes that maintain cells in an abnormal transcriptional state.

It might at first seem counterintuitive that processes involved in the uncontrolled proliferation and transformation that are characteristics of cancer could be useful intervention points in nonproliferative disorders, but in reality this is not so surprising. Epigenetic mechanisms control cell fate. Aberrant epigenetic processes can have several potential outcomes, depending on the enzymes and pathways involved, the specific cell type, interactions with the environment and so on. Given the large numbers of enzymes involved in epigenetic processes, a role only in cancer would be far more surprising than an involvement in multiple indications.



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