Lyotropic liquid crystal (LLC) systems that commonly consist of amphiphilic molecules and solvents can be classified into lamellar (La), cubic, hexagonal mesophases, and so on. In recent years, LLC systems have received considerable attention because of their excellent potential as drug vehicles.Among these systems, reversed cubic (Q2) and hexagonal mesophases (H2) are the most important and have been extensively investigated for their ability to sustain the release of a wide range of bioactives from low molecular weight drugs to proteins, peptides and nucleic acids.