Calcium phosphate biomaterials as bone drug delivery systems: a review

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A short review is proposed on the existing literature for the research performed in calcium phosphate (CaP) biomaterials used as drug delivery systems. In the first part, a brief update is given on the performance of both CaP ceramics and CaP cements. Second, a review of the research and clinical situation is developed for CaP materials already used as drug delivery systems.

Local drug delivery devices could reduce side-effects, improve the efficacy of existing drugs and open the door to entire classes of new treatments. Such combined systems are able to precisely control the timing of a drug release by adjusting the properties of the carriers.

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