A biological stabilization technology for peptide drugs: enzymatic introduction of thioether-bridges

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This review describes the biological technology of using Lactococcus lactis containing the nisin-modifying enzymes for producing thioether-stabilized therapeutic peptides.

The main limitation in the application of therapeutic peptides is their rapid degradation by proteolytic enzymes. Thioether-bridges in peptides confer strong resistance against proteolytic degradation, can modulate receptor interaction and extend delivery possibilities. Their enzymatic introduction is chemo-, regionand stereo-specific and allows the stabilization of medically and economically highly important therapeutic peptides. This emerging technology has huge potential for the development of a large number of novel highly effective peptide drugs.

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