Interference with islet-specific homing of autoreactive T cells: an emerging therapeutic strategy for type 1 diabetes

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In this review molecular mechanisms governing transendothelial migration of the diabetogenic effector cells are discussed and resulting pharmacological strategies are considered.

Pathogenesis of type 1 diabetes involves the activation of autoimmune T cells, consequent homing of activated lymphocytes to the pancreatic islets and ensuing destruction of insulin-producing beta cells. Interaction between activated lymphocytes and endothelial cells in the islets is the hallmark of the homing process.

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