Dendrimer-based drug and imaging conjugates: design considerations for nanomedical applications

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This review focuses on several crucial issues related to those dendrimer features, namely the role of dendrimers as nanoscaffolding and nanocontainers, crucial principles that might be invoked for improving dendrimer cytotoxicity properties, understanding dendrimer cellular transport mechanisms and the exciting role of dendrimers as high-contrast MRI imaging agents.

The review concludes with a brief survey of translational efforts from research and development phases to clinical trials that are actively emerging.

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