Aurora-A kinase inhibitor scaffolds and binding modes

29 May 2012
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Aixia Yan, Liyu Wang, Shuyu Xu and Jun Xu summarize the common binding modes of Aurora-A kinase inhibitors, the hot spot residues in the binding sites and the privileged inhibitor structures. Their review of the reported chemical scaffolds of Aurora-A kinase inhibitors and their binding modes could provide a useful framework from which new design strategies for inhibitors might be assessed or developed.