HIV-1 proteins join the family of LIM kinase partners. New roads open up for HIV-1 treatment

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In this article Fabrizio Manetti discusses the area of LIM kinases and how the development of inhibitors of these enzymes might be a successful approach to the treatment of AIDS.

LIM kinases (LIMK) exert their functions by recruiting many macromolecular partners that could contribute to modulate LIMK activity in a positive or negative manner. In addition to proteins that interact with LIMK in human or animal cells and tissues, recent data show that LIMK activity is also influenced by HIV-1 viral proteins. These results suggest new strategies for the treatment of HIV-1 infection, based on the inhibition of LIMK-mediated cofilin inactivation and consequent actin depolymerization.

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