Characterization of protein therapeutics by mass spectrometry: recent developments and future directions

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This review article by Guodong Chen, Bethanne M. Warrack, Angela K. Goodenough, Hui Wei, David B. Wang-Iverson and Adrienne A. Tymiak describes recent developments and future trends in the characterization of protein therapeutics using mass spectrometry.

They discuss top-down mass spectrometry for the characterization of protein modifications, hydrogen/deuterium exchange mass spectrometry and ion mobility mass spectrometry methods for higher order protein structure studies. Quantitative analysis of protein therapeutics (in vivo) by mass spectrometry as an orthogonal approach to immunoassay for pharmacokinetics studies is also illustrated.

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