Fragment screening to predict druggability (ligandability) and lead discovery success
17 July 2012
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In this article Fredrik N.B. Edfeldt et al. discuss using an initial fragment screen to determine the ligandability of new targets. An insightful analysis of the ligandability score, the success of HTS and entry into hit-to-lead is presented for 36 targets.
Furthermore, the authors discuss ways to interpret ligandability data that use the available information content more conservatively.