Label-free whole-cell assays: expanding the scope of GPCR screening

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Clay W Scott and Matthew F. Peters review emerging data evaluating impedance- and optical-based label-free instruments for GPCR drug discovery.

In comparison with traditional GPCR assays, they highlight strengths, weaknesses and future opportunities for label-free biosensors.  They also review label-free GPCR drug discovery applications that have been validated to date.

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