The formulation of polyhedral boranes for the boron neutron capture therapy of cancer

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The early promise of boron neutron capture therapy as a method for the treatment of cancer has been inhibited by the inherent toxicity associated with therapeutically useful doses of 10B-containing pharmacophores, the need for target-tissue specificity and the challenges imposed by biological barriers.

In this article Gianpiero Calabrese, John J. Nesnas, Eugen Barbu, Dimitris Fatourosand John Tsibouklis discuss how developments in the synthetic chemistry of polyhedral boranes have addressed issues oftoxicity to a considerable extent. They also discuss the optimisation of the transport and the delivery of boronated agentsto the site of action and the development ofinnovative formulation strategies.

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