Biotherapeutics News for January 2014

Biotherapeutics News Archive

World’s tiniest drug cabinets could be attached to cancerous cells for long term treatment World’s tiniest drug cabinets could be attached to cancerous cells for long term treatment

Reservoirs of pharmaceuticals could be manufactured to bind specifically to infected tissue such as cancer cells for slow, concentrated delivery of drug treatments, according to new research published in ACS Macro Letters. The findings, from the University of Copenhagen and the Institut Laue-Langevin (ILL), came as a result of neutron reflectometry studies at the world’s leading neutron source in Grenoble, France. They could provide a way to reduce dosages and the frequency of injections administered to patients undergoing a wide variety of treatments, as well as minimising side effects of over-dosing.

Roche reports new method for efficiently transporting antibodies across the Blood-Brain Barrier Roche reports new method for efficiently transporting antibodies across the Blood-Brain Barrier

Results published in Neuron demonstrate efficacy in preclinical mouse models of Alzheimer’s diseaseYesterday the scientific journal Neuron published results on the Roche-designed Brain Shuttle technology that efficiently transfers investigational antibodies from the blood through the blood-brain barrier (BBB) into the brain in preclinical models1. Roche Pharma Early Research and Development (pRED) scientists found that such enhanced transfer of antibodies through the BBB was associated with a marked improvement in amyloid reduction in the brain of a mouse model of Alzheimer’s disease.