Medicinal chemistry strategies in follow-on drug discovery

Stephen Carney

This article was the most downloaded article in the period Q2 2009. A common theme appears with many of our most popular articles in that they frequently relate to medicinal chemistry strategy or practice. I hope that you enjoy this article.


Drug discovery targeting novel mechanisms has become extremely expensive and risky. The annual first in-class drug approvals have not been satisfactory in the past decade (two to six per year) despite an increased R&D budget. Follow-on programs targeting proven mechanisms are less risky and costly but can produce drugs with meaningful differentiations and thus can play an important supporting role.This article will discuss the medicinal chemistry strategies that have been utilized by the pharmaceutical industry to exploit validated therapeutic targets.

Share this article

More services


This article is featured in:
Medicinal Chemistry


Comment on this article

You must be registered and logged in to leave a comment about this article.