Our February issue review highlights include:
- Fetal hypoxia and programming of matrix metalloproteinases
- Mesopore-assisted profiling strategies in clinical proteomics
- The value of in silico chemistry in the safety of chemicals
- Biomimetic tissues on a chip for drug discovery
Cover Story
The leading story of this issue of Drug Discovery Today, by Wenni Tong and Lubo Zhang summarizes current knowledge of the mechanisms by which fetal hypoxia induces the imbalance of MMPs, TIMPs and collagen expression patterns, resulting in growth restriction and aberrant tissue remodeling in the developing heart and brain. Collectively, this information could lead to the development of preventive diagnoses and therapeutic strategies in the fetal programming of cardiovascular and neurological disorders.
Click here to view the February issue of Drug Discovery Today in ScienceDirect